溴乙烯基脱氧尿苷与干扰素治疗溃疡性疱疹性角膜炎：一项双盲研究。
Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.
作者信息
van Bijsterveld O P, Meurs P J, de Clercq E, Maudgal P C
机构信息
Royal Dutch Eye Clinic, Utrecht, The Netherlands.
出版信息
Br J Ophthalmol. 1989 Aug;73(8):604-7. doi: 10.1136/bjo.73.8.604.
Abstract
Bromovinyldeoxyuridine is a potent and safe antiherpes compound that in combination with a placebo treatment promoted the partial and complete healing of herpetic epithelial disease in 22 patients in average times of 4-6 days and 8.5 days respectively. However, when BVDU was combined with 1.5 X 10(6) IU of recombinant a 2C interferon, partial and complete healing times for keratitis in 19 patients were reduced to 2-6 days and 4-6 days respectively. No toxic effects of the medications were observed in any patient.
摘要
溴乙烯基脱氧尿苷是一种强效且安全的抗疱疹化合物，与安慰剂治疗相结合时，分别使22例疱疹性上皮病患者平均在4 - 6天和8.5天实现部分和完全愈合。然而，当溴乙烯基脱氧尿苷与1.5×10⁶国际单位的重组α2C干扰素联合使用时，19例角膜炎患者的部分和完全愈合时间分别缩短至2 - 6天和4 - 6天。未观察到任何患者出现药物毒性作用。
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