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1
Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.溴乙烯基脱氧尿苷与干扰素治疗溃疡性疱疹性角膜炎：一项双盲研究。
Br J Ophthalmol. 1989 Aug;73(8):604-7. doi: 10.1136/bjo.73.8.604.
2
Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.溴乙烯脱氧尿苷（BVDU）和三氟胸苷（TFT）治疗树枝状角膜溃疡的随机双盲试验
Br J Ophthalmol. 1991 Nov;75(11):649-51. doi: 10.1136/bjo.75.11.649.
3
Bromovinyldeoxyuridine treatment of herpetic keratitis clinically resistant to other antiviral agents.用溴乙烯基脱氧尿苷治疗对其他抗病毒药物临床耐药的疱疹性角膜炎。
Curr Eye Res. 1991;10 Suppl:193-9. doi: 10.3109/02713689109020379.
4
Combination therapy of recombinant human alpha 2 interferon and acyclovir in the treatment of herpes simplex keratitis.重组人α2干扰素与阿昔洛韦联合治疗单纯疱疹性角膜炎
Antiviral Res. 1985;Suppl 1:225-8. doi: 10.1016/s0166-3542(85)80032-2.
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Combination therapy for dendritic keratitis with acyclovir and alpha-interferon.
Arch Ophthalmol. 1983 Dec;101(12):1866-8. doi: 10.1001/archopht.1983.01040020868006.
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Bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration: a double blind controlled study.溴乙烯基脱氧尿苷（BVDU）和三氟胸苷（TFT）治疗树枝状角膜溃疡的双盲对照研究。
Curr Eye Res. 1991;10 Suppl:183-7. doi: 10.3109/02713689109020377.
7
Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine.实验性基质型单纯疱疹性角膜炎。局部应用溴乙烯脱氧尿苷和三氟尿苷治疗的影响。
Arch Ophthalmol. 1982 Apr;100(4):653-6. doi: 10.1001/archopht.1982.01030030655027.
8
Evaluation of bromovinyldeoxyuridine-related compounds in the treatment of experimental herpes simplex keratitis.溴乙烯基脱氧尿苷相关化合物治疗实验性单纯疱疹性角膜炎的评估。
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Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷局部治疗单纯疱疹性角膜炎的疗效
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(4):261-8. doi: 10.1007/BF00455033.
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[Clinical trials of interferon in ophthalmology].[干扰素在眼科的临床试验]
Gan To Kagaku Ryoho. 1984 Feb;11(2):212-20.

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Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.单纯疱疹病毒性上皮性角膜炎的抗病毒治疗及其他治疗干预措施。
Cochrane Database Syst Rev. 2015 Jan 9;1(1):CD002898. doi: 10.1002/14651858.CD002898.pub5.
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Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.单纯疱疹病毒性上皮性角膜炎的抗病毒治疗及其他治疗干预措施。
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Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.溴乙烯脱氧尿苷（BVDU）和三氟胸苷（TFT）治疗树枝状角膜溃疡的随机双盲试验
Br J Ophthalmol. 1991 Nov;75(11):649-51. doi: 10.1136/bjo.75.11.649.

本文引用的文献

1
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷局部治疗单纯疱疹性角膜炎的疗效
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(4):261-8. doi: 10.1007/BF00455033.
2
Oral and topical treatment of experimental herpes simplex iritis with bromovinyldeoxyuridine.用溴乙烯脱氧尿苷对实验性单纯疱疹性虹膜炎进行口服和局部治疗。
Arch Ophthalmol. 1982 Aug;100(8):1337-40. doi: 10.1001/archopht.1982.01030040315025.
3
Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine.实验性基质型单纯疱疹性角膜炎。局部应用溴乙烯脱氧尿苷和三氟尿苷治疗的影响。
Arch Ophthalmol. 1982 Apr;100(4):653-6. doi: 10.1001/archopht.1982.01030030655027.
4
Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus.抗疱疹药物对不同水痘-带状疱疹病毒株的疗效比较
J Infect Dis. 1983 Mar;147(3):576-84. doi: 10.1093/infdis/147.3.576.
5
The relationship between incorporation of E-5-(2-Bromovinyl)-2'-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity.E-5-(2-溴乙烯基)-2'-脱氧尿苷掺入单纯疱疹病毒1型DNA与病毒感染性及DNA完整性之间的关系。
J Biol Chem. 1983 Jan 25;258(2):792-5.
6
Differential phosphorylation of (E)-5-(2-bromovinyl)-2'-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus.单纯疱疹病毒1型和2型以及水痘带状疱疹病毒的胸苷酸激酶对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷单磷酸的差异磷酸化作用
Mol Pharmacol. 1982 Mar;21(2):432-7.
7
In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.水痘带状疱疹病毒对E-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物的体外敏感性
Antimicrob Agents Chemother. 1982 Jan;21(1):33-8. doi: 10.1128/AAC.21.1.33.
8
Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells.E-5-(2-卤代乙烯基)-2'-脱氧尿苷掺入单纯疱疹病毒1型感染细胞的脱氧核糖核酸中。
J Biol Chem. 1982 Jan 25;257(2):603-6.
9
Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins.5-（2-卤代乙烯基）-2'-脱氧尿苷对不同来源的脱氧胸苷激酶的差异亲和力。
Mol Pharmacol. 1981 Jul;20(1):230-3.
10
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.关于（E）-5-（2-溴乙烯基）-2'-脱氧尿苷对疱疹病毒复制的选择性抑制机制
Proc Natl Acad Sci U S A. 1981 May;78(5):2698-702. doi: 10.1073/pnas.78.5.2698.

溴乙烯基脱氧尿苷与干扰素治疗溃疡性疱疹性角膜炎：一项双盲研究。

Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.

作者信息

van Bijsterveld O P, Meurs P J, de Clercq E, Maudgal P C

机构信息

Royal Dutch Eye Clinic, Utrecht, The Netherlands.

出版信息

Br J Ophthalmol. 1989 Aug;73(8):604-7. doi: 10.1136/bjo.73.8.604.

DOI:10.1136/bjo.73.8.604
PMID:2669938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1041826/
Abstract

Bromovinyldeoxyuridine is a potent and safe antiherpes compound that in combination with a placebo treatment promoted the partial and complete healing of herpetic epithelial disease in 22 patients in average times of 4-6 days and 8.5 days respectively. However, when BVDU was combined with 1.5 X 10(6) IU of recombinant a 2C interferon, partial and complete healing times for keratitis in 19 patients were reduced to 2-6 days and 4-6 days respectively. No toxic effects of the medications were observed in any patient.

摘要

溴乙烯基脱氧尿苷是一种强效且安全的抗疱疹化合物，与安慰剂治疗相结合时，分别使22例疱疹性上皮病患者平均在4 - 6天和8.5天实现部分和完全愈合。然而，当溴乙烯基脱氧尿苷与1.5×10⁶国际单位的重组α2C干扰素联合使用时，19例角膜炎患者的部分和完全愈合时间分别缩短至2 - 6天和4 - 6天。未观察到任何患者出现药物毒性作用。