Yon Dong Keon, An Jaewoo, Ha Eun Kyo, Jee Hye Mi, Izuhara Kenji, Ono Junya, Jung Young Ho, Lee Kyung Suk, Sheen Youn Ho, Baek Heysung, Han Man Yong
Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
Allergy Asthma Immunol Res. 2018 Nov;10(6):716-721. doi: 10.4168/aair.2018.10.6.716.
Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP₂₀₁₆) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children. Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.
流行病学研究表明，接触导致气道刺激和炎症的烟草烟雾往往会降低成年人的血清骨膜蛋白浓度。我们现在对135名参加2016年城南儿童幸福特应性项目（SAP₂₀₁₆）队列研究的一年级7岁韩国学生进行前瞻性横断面研究。据我们所知，这是第一项表明儿童血清骨膜蛋白浓度与接触二甲苯和甲醛之间存在显著负相关的研究。我们的研究结果表明，在将血清骨膜蛋白水平用作过敏性疾病的标志物时需要谨慎，因为接触挥发性有机化合物和甲醛可能会混淆这些结果的解释。
