Brazilian Bioscience National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas- SP, Brazil.
Curr Med Chem. 2019;26(36):6564-6571. doi: 10.2174/0929867325666181009152844.
Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) is a cofactor used in different anabolic reactions, such as lipid and nucleic acid synthesis, and for oxidative stress defense. NADPH is essential for parasite growth and viability. In trypanosomatid parasites, NADPH is supplied by the oxidative branch of the pentose phosphate pathway and by enzymes associated with the citric acid cycle. The present article will review recent achievements that suggest glucose-6-phosphate dehydrogenase and the cytosolic isoform of the malic enzyme as promising drug targets for the discovery of new drugs against Trypanosoma cruzi and T. brucei. Topics involving an alternative strategy in accelerating T. cruzi drug-target validation and the concept of drug-target classification will also be revisited.
还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）是一种用于不同合成反应的辅助因子，如脂质和核酸合成，以及用于氧化应激防御。NADPH 对寄生虫的生长和存活至关重要。在原生动物寄生虫中，NADPH 由戊糖磷酸途径的氧化分支和与柠檬酸循环相关的酶提供。本文将综述最近的研究成果，这些成果表明葡萄糖-6-磷酸脱氢酶和苹果酸酶的细胞质同工酶是针对克氏锥虫和布氏锥虫发现新药的有前途的药物靶点。还将重新讨论加速克氏锥虫药物靶点验证的替代策略和药物靶点分类的概念。
