Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Theranostics. 2021 Mar 4;11(10):4839-4857. doi: 10.7150/thno.56747. eCollection 2021.
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative metabolism and are associated with a number of human diseases. The reprogramming of redox metabolism induces abnormal accumulation of ROS in cancer cells. It has been widely accepted that ROS play opposite roles in tumor growth, metastasis and apoptosis according to their different distributions, concentrations and durations in specific subcellular structures. These double-edged roles in cancer progression include the ROS-dependent malignant transformation and the oxidative stress-induced cell death. In this review, we summarize the notable literatures on ROS generation and scavenging, and discuss the related signal transduction networks and corresponding anticancer therapies. There is no doubt that an improved understanding of the sophisticated mechanism of redox biology is imperative to conquer cancer.
活性氧（ROS）作为氧化代谢过程中产生的细胞信号分子，与许多人类疾病有关。氧化还原代谢的重编程导致癌细胞中 ROS 的异常积累。人们普遍认为，ROS 根据其在特定亚细胞结构中的不同分布、浓度和持续时间，在肿瘤生长、转移和凋亡中发挥相反的作用。在癌症进展中，这些双刃剑作用包括 ROS 依赖性恶性转化和氧化应激诱导的细胞死亡。在这篇综述中，我们总结了关于 ROS 产生和清除的显著文献，并讨论了相关的信号转导网络和相应的抗癌治疗方法。毫无疑问，深入了解氧化还原生物学的复杂机制对于攻克癌症至关重要。
