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Vitamin K1 cream significantly reduces incidence and severity of cetuximab-related acneiform skin rash in women: a post hoc analysis of the EVITA trial.

作者信息

Gaiser M R, Lorenzen S, Merx K, Trojan J, Ocvirk J, Ettrich T J, Al-Batran S-E, Schulz H, Homann N, Feustel H-P, Schatz M, Kripp M, Schulte N, Heeger S, Vlassak S, Koch W, Hofheinz R-D

机构信息

Department of Dermatology Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Medical Clinic III, University of Munich, Munich, Germany.

出版信息

Ann Oncol. 2018 Dec 1;29(12):2393-2395. doi: 10.1093/annonc/mdy451.

DOI:10.1093/annonc/mdy451
PMID:30307464
Abstract
摘要

相似文献

1
Vitamin K1 cream significantly reduces incidence and severity of cetuximab-related acneiform skin rash in women: a post hoc analysis of the EVITA trial.维生素K1乳膏可显著降低女性西妥昔单抗相关痤疮样皮疹的发生率和严重程度：EVITA试验的事后分析
Ann Oncol. 2018 Dec 1;29(12):2393-2395. doi: 10.1093/annonc/mdy451.
2
Topical vitamin K1 may not be effective in preventing acneiform rash during cetuximab treatment in patients with metastatic colorectal cancer.局部使用维生素 K1 可能无法有效预防转移性结直肠癌患者接受西妥昔单抗治疗时出现痤疮样皮疹。
Eur J Dermatol. 2013 Jan-Feb;23(1):77-82. doi: 10.1684/ejd.2012.1899.
3
Evaluation of EGFR inhibitor-mediated acneiform skin toxicity within the double-blind randomized EVITA trial: A thorough gender-specific analysis using the WoMo score.评价 EGFR 抑制剂诱导痤疮样皮肤毒性的双盲随机 EVITA 试验：使用 WoMo 评分进行全面的性别特异性分析。
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Prospective, observational practice survey of applied skin care and management of cetuximab-related skin reactions: PROSKIN study.应用皮肤护理和西妥昔单抗相关皮肤反应管理的前瞻性、观察性实践调查：PROSKIN 研究。
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EVITA-a double-blind, vehicle-controlled, randomized phase II trial of vitamin K1 cream as prophylaxis for cetuximab-induced skin toxicity.EVITA 试验：一项维生素 K1 乳膏预防西妥昔单抗相关性皮肤毒性的双盲、赋形剂对照、随机Ⅱ期临床试验
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Pilot clinical trial on the efficacy of prophylactic use of vitamin K1-based cream (Vigorskin) to prevent cetuximab-induced skin rash in patients with metastatic colorectal cancer.维生素 K1 乳膏（Vigorskin）预防西妥昔单抗致转移性结直肠癌患者皮疹的疗效的初步临床试验。
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Topical therapy with nadifloxacin cream and prednicarbate cream improves acneiform eruptions caused by the EGFR-inhibitor cetuximab - A report of 29 patients.纳地氟沙星乳膏和泼尼卡酯乳膏外用治疗表皮生长因子受体抑制剂西妥昔单抗所致痤疮样皮疹 29 例报告
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A prospective, randomized, double-blinded, split-face/chest study of prophylactic topical dapsone 5% gel versus moisturizer for the prevention of cetuximab-induced acneiform rash.一项关于5%氨苯砜凝胶与保湿剂预防性局部应用预防西妥昔单抗诱导的痤疮样皮疹的前瞻性、随机、双盲、半脸/胸部对照研究。
J Am Acad Dermatol. 2017 Sep;77(3):577-579. doi: 10.1016/j.jaad.2017.03.039.
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Topical aloe vera for the treatment of cetuximab-related acneiform rash in colorectal cancer: A case report.局部用芦荟治疗结直肠癌患者西妥昔单抗相关痤疮样皮疹：病例报告。
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[Therapy of severe cetuximab-induced acneiform eruptions with oral retinoid, topical antibiotic and topical corticosteroid].[口服维甲酸、外用抗生素和外用皮质类固醇治疗西妥昔单抗引起的严重痤疮样皮疹]
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引用本文的文献

1
The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.外用维生素K1对转移性结直肠癌患者西妥昔单抗所致皮疹的治疗效果
Adv Biomed Res. 2023 Nov 29;12:260. doi: 10.4103/abr.abr_141_23. eCollection 2023.
2
Menahydroquinone-4 may play a key role in regulating CCL5 expression induced by epidermal growth factor receptor inhibitors.间苯二酚-4 可能在调节表皮生长因子受体抑制剂诱导的 CCL5 表达中发挥关键作用。
Sci Rep. 2023 Dec 13;13(1):22102. doi: 10.1038/s41598-023-49627-8.
3
Evaluation of EGFR inhibitor-mediated acneiform skin toxicity within the double-blind randomized EVITA trial: A thorough gender-specific analysis using the WoMo score.
评价 EGFR 抑制剂诱导痤疮样皮肤毒性的双盲随机 EVITA 试验：使用 WoMo 评分进行全面的性别特异性分析。
Cancer Med. 2019 Aug;8(9):4169-4175. doi: 10.1002/cam4.2132. Epub 2019 Jun 14.