Faculty of Medicine, Department of Medical Oncology, Ankara University, Ankara, Turkey.
J Oncol Pharm Pract. 2021 Mar;27(2):480-484. doi: 10.1177/1078155220937751. Epub 2020 Jul 5.
Colorectal cancer is one of the most common cancers in the world. Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor which provides survival benefit when combined with chemotherapy in RAS wild type metastatic colorectal cancer. Cutaneous toxicities associated with cetuximab have a significant impact on patient quality of life, treatment continuation and healthcare resource utilization.
A 60-year-old male patient presented with fatigue, weight loss and abdominal pain. Two closely located malignant polypoid lesions were detected in the sigmoid colon, and pathological examination revealed colonic adenocarcinoma. Thorax, abdominal and pelvic computed tomography showed metastases. FOLFOX chemotherapy and cetuximab were started. The patient developed acneiform rash firstly in his face, although prophylactic vitamin K1 0.1% containing cream was given. He was given mild potency topical corticosteroid and doxycycline. The lesions progressed to his front and back body. He did not want to use topical vitamin K1 cream, topical steroid and doxycycline tablets. Instead, he wanted to use aloe vera extract which he produced from the leaves of the plant. Patient's lesions were regressed significantly.
The most common and earliest skin toxicity is acneiform rash which affects 60 to 80% of the patients. In this case, cetuximab-related severe acneiform rash was effectively treated by topical aloe vera. Topical aloe vera may be used in the management of cetuximab-related cutaneous toxicities without any side effect.
结直肠癌是世界上最常见的癌症之一。西妥昔单抗是一种表皮生长因子受体（EGFR）抑制剂，与化疗联合用于 RAS 野生型转移性结直肠癌时可提供生存获益。西妥昔单抗相关的皮肤毒性对患者的生活质量、治疗的连续性和医疗保健资源的利用有重大影响。
一名 60 岁男性患者因疲劳、体重减轻和腹痛就诊。在乙状结肠发现两个紧密相邻的恶性息肉状病变，病理检查显示为结肠腺癌。胸部、腹部和盆腔 CT 显示转移。开始给予 FOLFOX 化疗和西妥昔单抗。患者首先在面部出现痤疮样皮疹，尽管给予了预防用 0.1%维生素 K1 乳膏。给予了轻度强力外用皮质类固醇和多西环素。病变进展到他的前后身体。他不想使用外用维生素 K1 乳膏、外用类固醇和多西环素片。相反，他想用他从植物叶子中提取的芦荟提取物。患者的皮损明显消退。
最常见和最早的皮肤毒性是痤疮样皮疹，影响 60%至 80%的患者。在本例中，西妥昔单抗相关的严重痤疮样皮疹经外用芦荟有效治疗。外用芦荟可用于管理西妥昔单抗相关的皮肤毒性，无任何副作用。
