Sinigaglia F, Matile H, Pink J R
Eur J Immunol. 1987 Feb;17(2):187-92. doi: 10.1002/eji.1830170206.
This report describes the isolation, and the phenotypic and functional characterization of Plasmodium falciparum-specific human T lymphocyte clones (TLC) obtained from 2 acutely infected and 4 clinically immune donors. Approximately one third of the TLC obtained from the acutely infected patients had the phenotype CD8+/CD4-. No such clones were obtained from the clinically immune donors. P. falciparum-specific, major histocompatibility complex-restricted CD8+ clones can lyse unrelated tumor cell targets in the presence of anti-CD3 antibodies, suggesting that these clones have cytotoxic potential. Conversely no killing was obtained with two CD4+ P. falciparum-specific TLC, even in the presence of anti-CD3 antibody, In addition the helper function of a CD4+ clone was demonstrated in a T/B cell cooperation system.
本报告描述了从2名急性感染和4名临床免疫供体中获得的恶性疟原虫特异性人类T淋巴细胞克隆（TLC）的分离、表型和功能特征。从急性感染患者中获得的TLC约有三分之一具有CD8+/CD4-表型。从临床免疫供体中未获得此类克隆。恶性疟原虫特异性、主要组织相容性复合体限制的CD8+克隆在抗CD3抗体存在的情况下可裂解无关的肿瘤细胞靶标，表明这些克隆具有细胞毒性潜力。相反，两个恶性疟原虫特异性CD4+TLC即使在抗CD3抗体存在的情况下也未产生杀伤作用。此外，在T/B细胞合作系统中证明了一个CD4+克隆的辅助功能。
