芝麻开门：解锁诺如病毒感染之门的新钥匙。

Open Sesame: New Keys to Unlocking the Gate to Norovirus Infection.

机构信息

Institute of Virology and Cell Biology, University of Luebeck, Luebeck, Germany.

出版信息

Cell Host Microbe. 2018 Oct 10;24(4):463-465. doi: 10.1016/j.chom.2018.09.018.

DOI:10.1016/j.chom.2018.09.018

Abstract

Three recent papers highlight the impact of an entry receptor on murine norovirus pathogenesis. CD300lf was shown to be the first proteinaceous entry receptor for a norovirus, specialized intestinal epithelial cells constitute the reservoir for persistence, and a new link between the receptor and a lipid biosynthetic enzyme was revealed.

摘要

三篇近期论文强调了进入受体对鼠诺如病毒发病机制的影响。CD300lf 被证实为诺如病毒的第一个蛋白进入受体，特化的肠上皮细胞构成持续性的储存库，并且揭示了受体和脂质生物合成酶之间的新联系。