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V 组磷酯酶 A 的有害和保护作用：当前观点和未来方向。

Harmful and protective roles of group V phospholipase A: Current perspectives and future directions.

机构信息

Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

出版信息

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):819-826. doi: 10.1016/j.bbalip.2018.10.001. Epub 2018 Oct 8.

DOI:10.1016/j.bbalip.2018.10.001
PMID:30308324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6432776/
Abstract

Group V Phospholipase A (Pla2g5) is a member of the PLA family of lipid-generating enzymes. It is expressed in immune and non-immune cell types and is inducible during several pathologic conditions serving context-specific functions. In this review, we recapitulate the protective and detrimental functions of Pla2g5 investigated through preclinical and translational approaches. This article is part of a Special Issue entitled Novel functions of phospholipase A Guest Editors: Makoto Murakami and Gerard Lambeau.

摘要

组 V 磷脂酶 A（Pla2g5）是产生脂质的 PLA 酶家族的成员。它在免疫和非免疫细胞类型中表达，并在几种病理条件下诱导，发挥特定的功能。在这篇综述中，我们通过临床前和转化方法回顾了 Pla2g5 的保护和有害功能。本文是特刊的一部分，主题为“磷脂酶 A 的新功能”，客座编辑为 Makoto Murakami 和 Gerard Lambeau。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b615/6432776/65685c2b65e9/nihms-1509852-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b615/6432776/65685c2b65e9/nihms-1509852-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b615/6432776/65685c2b65e9/nihms-1509852-f0001.jpg

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