Department of Pathology and Laboratory Medicine, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA; Department of Pathology, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, 2120 E. Galbraith Road, Cincinnati, OH 45237, United States.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):784-788. doi: 10.1016/j.bbalip.2018.07.001. Epub 2018 Jul 9.
The group 1B phospholipase A (PLA2G1B) is a secreted phospholipase that catalyzes the hydrolytic removal of the sn-2 fatty acyl moiety from phospholipids. This enzyme is synthesized most abundantly in the pancreas and is also expressed in the lung. The first part of this review article focuses on the role of pancreatic-derived PLA2G1B in mediating lipid absorption and discusses how the PLA2G1B-derived metabolic product contributes to cardiometabolic diseases, including obesity, hyperinsulinemia, hyperlipidemia, and atherosclerosis. The anti-helminth properties of PLA2G1B will also be discussed. The second part of this review will focus on PLA2G1B expressed in the lung, and in vitro data suggest that how this enzyme may modulate lung inflammation via both hydrolytic activity-dependent and -dependent mechanisms. Finally, recent studies revealing a relationship between PLA2G1B and cancer will also be discussed. This article is part of a Special Issue entitled Novel functions of phospholipase A2 Guest Editors: Makoto Murakami and Gerard Lambeau.
1B 组磷脂酶 A（PLA2G1B）是一种分泌型磷脂酶，可催化磷脂 sn-2 脂肪酸酯的水解去除。这种酶在胰腺中合成最丰富，也在肺中表达。本文综述的第一部分重点介绍了胰腺来源的 PLA2G1B 在介导脂质吸收中的作用，并讨论了 PLA2G1B 衍生的代谢产物如何导致肥胖症、高胰岛素血症、高血脂症和动脉粥样硬化等代谢性疾病。还将讨论 PLA2G1B 的抗寄生虫特性。本文综述的第二部分将重点介绍在肺中表达的 PLA2G1B，体外数据表明，这种酶如何通过水解活性依赖和非依赖机制来调节肺炎症。最后，还将讨论最近揭示 PLA2G1B 与癌症之间关系的研究。本文是题为“磷脂酶 A2 的新功能”特刊的一部分，客座编辑为 Makoto Murakami 和 Gerard Lambeau。
