Department of Microbiology, IWWR, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Department of Microbiology, IWWR, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Curr Opin Chem Biol. 2019 Apr;49:39-44. doi: 10.1016/j.cbpa.2018.09.019. Epub 2018 Oct 8.
For decades rare earth elements (or lanthanides) were considered not to be involved in biological processes, until their discovery in the active site of the XoxF-type methanol dehydrogenase of the methanotrophic bacterium Methylacidiphilum fumariolicum SolV. Follow-up studies revealed the presence of lanthanides in other pyrroloquinoline quinone-containing enzymes involved in alcohol metabolism. This review discusses the biochemistry of the lanthanide-dependent enzymes and the ability of these metals of influencing the gene expression and the type of methanol dehydrogenase used by microorganisms. Furthermore, it highlights novel insights on the uptake mechanism of rare earth elements into bacterial cells.
几十年来，人们一直认为稀土元素（或镧系元素）不参与生物过程，直到它们在产甲烷菌 Methylacidiphilum fumariolicum SolV 的 XoxF 型甲醇脱氢酶的活性部位被发现。后续研究表明，在其他参与酒精代谢的含吡咯并喹啉醌的酶中也存在镧系元素。这篇综述讨论了镧系元素依赖酶的生物化学以及这些金属影响基因表达和微生物使用的甲醇脱氢酶类型的能力。此外，它还强调了关于稀土元素进入细菌细胞的摄取机制的新见解。
