Estime Stephen R, Berg Sheri M, Henry Michael E
From the Department of Anesthesia, Critical Care and Pain Medicine, and.
Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
J ECT. 2019 Jun;35(2):133-134. doi: 10.1097/YCT.0000000000000543.
Clozapine-induced gastric hypomotility (CIGH) is an underreported, underrecognized effect from high-dose clozapine. In this report, we present a patient with treatment refractory schizophrenia receiving high-dose clozapine who aspirated during general anesthesia for electroconvulsive therapy. To our knowledge, this is the first report of aspiration under general anesthesia as a result of CIGH and highlights the potential dangers high-dose clozapine can pose on patients undergoing electroconvulsive therapy with unrecognized CIGH.
氯氮平引起的胃动力不足（CIGH）是高剂量氯氮平一种未得到充分报告和认识的效应。在本报告中，我们介绍了一名接受高剂量氯氮平治疗的难治性精神分裂症患者，该患者在接受全麻下的电休克治疗时发生了误吸。据我们所知，这是首例因CIGH导致全麻下误吸的报告，并突出了高剂量氯氮平对未被识别出CIGH的接受电休克治疗患者可能造成的潜在危险。
