Kavanagh T J, Chang C C, Trosko J E
Fundam Appl Toxicol. 1987 Jan;8(1):127-31. doi: 10.1016/0272-0590(87)90108-4.
Firemaster BP-6 (FM), a mixture of polybrominated biphenyls (PBB), and the congeners 2,2',4,4',5,5'-hexabromobiphenyl (245-HBB), 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB), and 3,3',4,4'-tetrabromobiphenyl (34-TBB) were tested for their ability to inhibit cell-cell communication between human teratocarcinoma cells in culture. Both FM and 245-HBB were capable of inhibiting cell-cell communication in these cells, with only slight effects on cell survival. 345-HBB was highly cytotoxic, but did not show the ability to interrupt cell-cell communication. 34-TBB was moderately cytotoxic and was also ineffective at blocking cell-cell communication. The results agree with previously published findings in Chinese hamster V79 cells, and are in accordance with proposed structure-activity relationships for these compounds. Inhibition of cell-cell communication, either directly (FM and 245-HBB) or indirectly through necrosis-induced compensatory hyperplasia (345-HBB), may be involved in the promotion of hepatocellular neoplasms by these compounds.
防火剂BP - 6（FM），一种多溴联苯（PBB）混合物，以及同系物2,2',4,4',5,5'-六溴联苯（245 - HBB）、3,3',4,4',5,5'-六溴联苯（345 - HBB）和3,3',4,4'-四溴联苯（34 - TBB），针对它们抑制培养的人畸胎瘤细胞间细胞通讯的能力进行了测试。FM和245 - HBB都能够抑制这些细胞间的细胞通讯，对细胞存活仅有轻微影响。345 - HBB具有高度细胞毒性，但未表现出中断细胞间通讯的能力。34 - TBB具有中度细胞毒性，在阻断细胞间通讯方面也无效。这些结果与先前发表的关于中国仓鼠V79细胞的研究结果一致，并且符合这些化合物的结构 - 活性关系推测。细胞间通讯的抑制，无论是直接的（FM和245 - HBB）还是通过坏死诱导的代偿性增生间接产生的（345 - HBB），都可能与这些化合物促进肝细胞肿瘤有关。
