Tsushimoto G, Trosko J E, Chang C C, Aust S D
Carcinogenesis. 1982;3(2):181-5. doi: 10.1093/carcin/3.2.181.
Using an in vitro assay system to measure a form of cell-cell communication in Chinese hamster V79 cells, several purified polybrominated biphenyl (PBB) congeners were analyzed for their ability to affect colony-forming ability and "metabolic cooperation" in these cells. Results clearly demonstrate the assay's ability to distinguish differences in the cytotoxic and metabolic cooperation-inhibiting properties of these congeners related to their structure. It appears that if a carbon ortho to the bridge carbon of each phenyl ring is brominated, the molecule has the property by which metabolic cooperation is inhibited. The results suggest that several PBB congeners share at least one property associated with several known tumor promoters, such as the phorbol esters. Although we have not ruled out that the mixture of PBB congeners might contain initiators or that various PBB metabolites would be mutagen/initiators, based on these and other results, it was concluded that the reported carcinogenic potential of PBB seems to be mediated by its action as a tumor promoter, rather than as a complete carcinogen or an initiator.
利用体外分析系统来测量中国仓鼠V79细胞中的一种细胞间通讯形式，对几种纯化的多溴联苯（PBB）同系物影响这些细胞的集落形成能力和“代谢合作”的能力进行了分析。结果清楚地证明了该分析方法能够区分这些同系物与其结构相关的细胞毒性和代谢合作抑制特性的差异。似乎如果每个苯环桥碳邻位的一个碳原子被溴化，该分子就具有抑制代谢合作的特性。结果表明，几种PBB同系物至少具有一种与几种已知肿瘤促进剂（如佛波酯）相关的特性。尽管我们没有排除PBB同系物混合物可能含有引发剂，或者各种PBB代谢物可能是诱变剂/引发剂，但基于这些及其他结果，得出的结论是，PBB已报道的致癌潜力似乎是由其作为肿瘤促进剂的作用介导的，而不是作为完全致癌物或引发剂。
