用99mTc标记的2,6 - 二异丙基IDA的化学和生物学性质。
Chemical and biological properties of 2,6-diisopropyl IDA labelled with 99mTc.
作者信息
Zmbova B, Djokić D, Ninković D, Obradović V, Kostić K
出版信息
Int J Rad Appl Instrum A. 1987;38(1):35-40. doi: 10.1016/0883-2889(87)90233-4.
A procedure is described for the synthesis of 2,6-diisopropyl IDA (DISIDA) and for preparation of the radiopharmaceutical by "instant technique". The chemical parameters affecting the formation of the Sn(II)-DISIDA complex were also determined. Biological studies involved lyophylic measurements, determination of binding constants as well as rate of binding to proteins and biodistribution. Clinical investigation demonstrated good hepatobiliary features of this radiopharmaceutical.
描述了一种合成2,6-二异丙基IDA（DISIDA）以及通过“即时技术”制备放射性药物的方法。还确定了影响Sn（II）-DISIDA络合物形成的化学参数。生物学研究包括冻干测量、结合常数的测定以及与蛋白质的结合速率和生物分布。临床研究表明这种放射性药物具有良好的肝胆显像特征。
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