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一项比较锝-99m标记的二异丙基和对丁基IDA类似物在患者体内动力学的交叉研究。

A cross-over study comparing the kinetics of Tc-99m-labeled diisopropyl and p-butyl IDA analogs in patients.

作者信息

Hernandez M, Rosenthall L

出版信息

Clin Nucl Med. 1980 Apr;5(4):159-65. doi: 10.1097/00003072-198004000-00006.

DOI:10.1097/00003072-198004000-00006
PMID:6892797
Abstract

Tc-99m-diisopropyl-IDA (DISIDA) and Tc-99m-p-butyl-IDA (BIDA) were compared in each of 33 patients who had serum bilirubins ranging from normal to 23.5 mg/dl. DISIDA exhibited quantitatively a higher liver uptake and faster rate of washout at all levels of bilirubinemia. There was a tendency for BIDA to have a slower blood clearance, particularly in hyperbilirubinemias exceeding 5 mg/dl. On visual comparison of the images, BIDA failed to identify the gallbladder in three icteric patients and dilated biliary tracts in two others.

摘要

在33例血清胆红素水平从正常到23.5mg/dl的患者中,对锝-99m-二异丙基-亚氨基二乙酸(DISIDA)和锝-99m-对丁基-亚氨基二乙酸(BIDA)进行了比较。在所有胆红素血症水平下,DISIDA在肝脏摄取量上在数量上更高,洗脱速度更快。BIDA有血液清除较慢的趋势,尤其是在胆红素血症超过5mg/dl的情况下。在图像的视觉比较中,BIDA在3例黄疸患者中未能识别出胆囊,在另外2例患者中未能识别出扩张的胆道。

相似文献

1
A cross-over study comparing the kinetics of Tc-99m-labeled diisopropyl and p-butyl IDA analogs in patients.一项比较锝-99m标记的二异丙基和对丁基IDA类似物在患者体内动力学的交叉研究。
Clin Nucl Med. 1980 Apr;5(4):159-65. doi: 10.1097/00003072-198004000-00006.
2
A crossover study comparing the kinetics of Tc-99m-labeled diethyl- and diisopropyl-IDA.一项比较锝-99m标记的二乙基和二异丙基亚氨基二乙酸动力学的交叉研究。
Clin Nucl Med. 1980 Aug;5(8):352-8. doi: 10.1097/00003072-198008000-00004.
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Work in progress: clinical evaluation of Tc-99m-trimethylbromo-IDA and Tc-99m-diisopropyl-IDA for hepatobiliary imaging.进行中工作:锝-99m-三甲基溴代亚氨基二乙酸和锝-99m-二异丙基亚氨基二乙酸用于肝胆显像的临床评估。
Radiology. 1983 Jan;146(1):181-4. doi: 10.1148/radiology.146.1.6681569.
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Diagnostic utility of hepatobiliary scintigraphy with 99mTc-DISIDA in neonatal cholestasis.99mTc-DISIDA肝胆闪烁显像在新生儿胆汁淤积症中的诊断效用
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99mTc-diethyl-iodo-HIDA (JODIDA): a new hepatobiliary agent in clinical comparison with 99mTc-diisopropyl-HIDA (DISIDA) in jaundiced patients.
Eur J Nucl Med. 1986;12(7):346-50. doi: 10.1007/BF00263817.
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Radionuclide cholescintigraphic imaging: an evaluation of several 99mTc labelled hepatobiliary radiopharmaceuticals.放射性核素肝胆闪烁成像:几种99mTc标记的肝胆放射性药物的评估
Int J Rad Appl Instrum B. 1986;13(5):509-14. doi: 10.1016/0883-2897(86)90129-7.
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Preliminary clinical experience with Tc-99m disofenin as a biliary imaging agent in pediatrics.锝-99m 二乙基亚氨二乙酸作为儿科胆道显像剂的初步临床经验。
Clin Nucl Med. 1982 May;7(5):210-2. doi: 10.1097/00003072-198205000-00003.
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Comparison of biokinetics and biliary imaging parameters of four Tc-99m iminodiacetic acid derivatives in normal subjects.正常受试者中四种锝-99m亚氨基二乙酸衍生物的生物动力学和胆道成像参数比较。
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Preparation and biokinetic evaluation of various halogenated iminodiacetic acid-type compounds labeled with technetium-99m for hepatobiliary scintigraphy in the baboon (Papio ursinus) model.用99m锝标记的各种卤代亚氨基二乙酸类化合物在狒狒(山魈)模型中用于肝胆闪烁显像的制备及生物动力学评估。
Am J Physiol Imaging. 1990;5(1):3-7.
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Atlas of Tc-99m iminodiacetic acid (IDA) cholescintigraphy.锝-99m亚氨基二乙酸(IDA)肝胆闪烁造影图谱。
Clin Nucl Med. 1982 May;7(5):231-9. doi: 10.1097/00003072-198205000-00010.

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