Jahnke K
HNO. 1987 Jan;35(1):43-50.
The vestibular labyrinth of eight patients with Menière's disease obtained by translabyrinthine vestibular neurectomy or transtympanal labyrinthectomy was studied with the light microscope and transmission electron microscope. Previous invasive therapy was transtympanal application of gentamicin in one patient and endolymphatic sac surgery in two patients. Some of the pathological findings were unspecific, e.g. mucoid degeneration of the subepithelial spaces, fibrous long spacing collagen and high amount of lipofuscin in different cell types. Cuticular laminated structures were seen in some of the specimen. A most interesting finding was the discrepancy of large numbers of sub- and intraepithelial nerve fibers and a significant degeneration of vestibular sensory cells with vacuoles and filament bundles. This points out the importance of combining labyrinthectomy and vestibular neurectomy in late stages of unilateral Menière's disease.
对8例通过经迷路前庭神经切除术或经鼓室迷路切除术获取的梅尼埃病患者的前庭迷路进行了光镜和透射电镜研究。1例患者先前接受过鼓室内注射庆大霉素的侵入性治疗，2例患者接受过内淋巴囊手术。一些病理表现是非特异性的，例如上皮下间隙的黏液样变性、纤维长间距胶原以及不同细胞类型中大量的脂褐素。在一些标本中可见角质层状结构。一个最有趣的发现是大量上皮下和上皮内神经纤维与前庭感觉细胞显著变性并伴有空泡和细丝束之间的差异。这指出了在单侧梅尼埃病晚期联合迷路切除术和前庭神经切除术的重要性。
