College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, P. R. China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Nat Prod Res. 2022 Apr;36(7):1679-1685. doi: 10.1080/14786419.2020.1809397. Epub 2020 Aug 20.
Five new phloroglucinol derivatives were isolated from , and their structures were elucidated as brachyanones A-E () on the basis of the extensive spectroscopic analysis. Among them, compounds and exhibited significant inhibitory activity against -glucosidase with IC of 2.57 and 0.97 M, respectively. Furthermore, compound showed protein tyrosine phosphatase 1B (PTP1B) inhibitory effect with inhibition ratio of 89.42% at 100 M. This discovery indicates that phloroglucinol derivatives with long aliphatic chain possibly play an important role in antidiabetic activity of plants, and they could function as a promising antidiabetic agent.
从 中分离得到了 5 个新的间苯三酚衍生物，根据广泛的光谱分析，将它们的结构解析为 brachyanones A-E ()。其中，化合物 和 对 -葡萄糖苷酶表现出显著的抑制活性，IC 分别为 2.57 和 0.97 M。此外，化合物 对蛋白酪氨酸磷酸酶 1B（PTP1B）具有抑制作用，在 100 M 时抑制率为 89.42%。这一发现表明，具有长脂肪链的间苯三酚衍生物可能在 植物的抗糖尿病活性中发挥重要作用，它们可能是一种有前途的抗糖尿病药物。
