Ito S, Kinoshita T, Teishi M, Sasaki K
Nucleic Acids Symp Ser. 1986(17):21-4.
In the oxidation of thymine with hydroxyl radical generated from L-ascorbic acid/copper(II) ion/O system, four reaction products, thymine glycol(TG), N-formyl-N'-pyruvylurea(FPU), 5-hydroxymethyluracil(HMU) and 5-hydroxy-5-methyl barbituric acid(HMBA) were obtained. A reaction scheme was proposed to explain the products distribution observed.
在由L-抗坏血酸/铜(II)离子/O体系产生的羟基自由基氧化胸腺嘧啶的过程中,得到了四种反应产物,即胸腺嘧啶二醇(TG)、N-甲酰基-N'-丙酮酰脲(FPU)、5-羟甲基尿嘧啶(HMU)和5-羟基-5-甲基巴比妥酸(HMBA)。提出了一个反应方案来解释所观察到的产物分布情况。