Ito S, Kinoshita T, Sasaki K
Nucleic Acids Symp Ser. 1984(15):5-8.
Oxidation of thymine with O2 was promoted by copper(I) ion generated from reaction of L-ascorbic acid (AA) with copper (II) ion. The main oxidation products were thymine glycol (TG) and N-formyl-N'-pyruvylurea (FPU). At higher concentration of O2, formation of FPU was favored, while TG was dominant at higher Cu(II) ion and lower O2 concentrations. Reaction mechanism involving hydroxy thyminyl radical was proposed.
L-抗坏血酸（AA）与铜（II）离子反应生成的铜（I）离子可促进胸腺嘧啶与O₂的氧化反应。主要氧化产物为胸腺嘧啶二醇（TG）和N-甲酰基-N'-丙酮酰脲（FPU）。在较高的O₂浓度下，有利于FPU的形成，而在较高的铜（II）离子浓度和较低的O₂浓度下，TG占主导地位。提出了涉及羟基胸腺嘧啶自由基的反应机理。
