Repeated treatment with antidepressant drugs does not affect the benzodiazepine receptors in preincubated membrane preparations from mouse and rat brain.

Repeated injections or oral administration of antidepressants: imipramine, amitriptyline and desmethylimipramine (10 mg/kg twice daily for 21 days) did not alter significantly [3H]flunitrazepam binding to frozen-thawed preincubated membranes from the brains of mice or rats.