Cross J A, Horton R W
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, U.K.
Eur J Pharmacol. 1987 Sep 2;141(1):159-62. doi: 10.1016/0014-2999(87)90425-0.
Desmethylimipramine and zimelidine (10 mg/kg) were administered to rats once daily for 21 days. Chronic desmethylimipramine significantly reduced the number of 5HT2 binding sites in the frontal cortex but not hippocampus while chronic zimelidine did not affect 5HT2 binding in either brain region. The number and affinity of GABAB binding sites in the frontal cortex were unaltered by either drug.
给大鼠每日一次给予去甲丙咪嗪和齐美利定(10毫克/千克),持续21天。慢性给予去甲丙咪嗪显著减少了额叶皮质中5HT2结合位点的数量,但海马体中未减少,而慢性给予齐美利定对两个脑区的5HT2结合均无影响。两种药物均未改变额叶皮质中GABAB结合位点的数量和亲和力。