长期给予抗抑郁药苯乙肼、地昔帕明、氯米帕明或马普替林会降低大鼠脑中5-羟色胺2A受体的结合力，而不影响苯二氮䓬结合位点。
Chronic administration of the antidepressants phenelzine, desipramine, clomipramine, or maprotiline decreases binding to 5-hydroxytryptamine2A receptors without affecting benzodiazepine binding sites in rat brain.
作者信息
Todd K G, McManus D J, Baker G B
机构信息
Department of Psychiatry, University of Alberta, Edmonton, Canada.
出版信息
Cell Mol Neurobiol. 1995 Jun;15(3):361-70. doi: 10.1007/BF02089946.
Abstract
- The effects of chronic administration of five antidepressant drugs on the benzodiazepine and 5-HT2A binding sites in the same rat brain were assessed. 2. Clomipramine, desipramine, maprotiline, fluoxetine, and phenelzine (all 10 mg/kg/day) were administered s.c. for 21 days by Alzet osmotic minipumps. 3. Results showed that none of the drugs changed the density or affinity of benzodiazepine binding sites, yet at the same dose all the drugs with the exception of fluoxetine decreased binding to 5-HT2A receptors in the same animals.
摘要
- 评估了五种抗抑郁药物长期给药对同一大鼠脑内苯二氮䓬和5-HT2A结合位点的影响。2. 氯米帕明、地昔帕明、马普替林、氟西汀和苯乙肼（均为10毫克/千克/天）通过Alzet渗透微型泵皮下给药21天。3. 结果表明，这些药物均未改变苯二氮䓬结合位点的密度或亲和力，但在相同剂量下，除氟西汀外，所有药物均降低了同一动物体内5-HT2A受体的结合。
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