• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长期给予抗抑郁药苯乙肼、地昔帕明、氯米帕明或马普替林会降低大鼠脑中5-羟色胺2A受体的结合力，而不影响苯二氮䓬结合位点。

Chronic administration of the antidepressants phenelzine, desipramine, clomipramine, or maprotiline decreases binding to 5-hydroxytryptamine2A receptors without affecting benzodiazepine binding sites in rat brain.

作者信息

Todd K G, McManus D J, Baker G B

机构信息

Department of Psychiatry, University of Alberta, Edmonton, Canada.

出版信息

Cell Mol Neurobiol. 1995 Jun;15(3):361-70. doi: 10.1007/BF02089946.

DOI:10.1007/BF02089946
PMID:7553735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11563073/
Abstract
  1. The effects of chronic administration of five antidepressant drugs on the benzodiazepine and 5-HT2A binding sites in the same rat brain were assessed. 2. Clomipramine, desipramine, maprotiline, fluoxetine, and phenelzine (all 10 mg/kg/day) were administered s.c. for 21 days by Alzet osmotic minipumps. 3. Results showed that none of the drugs changed the density or affinity of benzodiazepine binding sites, yet at the same dose all the drugs with the exception of fluoxetine decreased binding to 5-HT2A receptors in the same animals.
摘要
  1. 评估了五种抗抑郁药物长期给药对同一大鼠脑内苯二氮䓬和5-HT2A结合位点的影响。2. 氯米帕明、地昔帕明、马普替林、氟西汀和苯乙肼（均为10毫克/千克/天）通过Alzet渗透微型泵皮下给药21天。3. 结果表明，这些药物均未改变苯二氮䓬结合位点的密度或亲和力，但在相同剂量下，除氟西汀外，所有药物均降低了同一动物体内5-HT2A受体的结合。

相似文献

1
Chronic administration of the antidepressants phenelzine, desipramine, clomipramine, or maprotiline decreases binding to 5-hydroxytryptamine2A receptors without affecting benzodiazepine binding sites in rat brain.长期给予抗抑郁药苯乙肼、地昔帕明、氯米帕明或马普替林会降低大鼠脑中5-羟色胺2A受体的结合力，而不影响苯二氮䓬结合位点。
Cell Mol Neurobiol. 1995 Jun;15(3):361-70. doi: 10.1007/BF02089946.
2
Maprotiline: an antidepressant with an unusual pharmacological profile.
J Pharmacol Exp Ther. 1986 Feb;236(2):307-12.
3
Chronic antidepressant drug treatment attenuates motor-suppressant effects of apomorphine without changing [3H]GBR 12935 binding.
Eur J Pharmacol. 1993 Nov 9;249(2):125-31. doi: 10.1016/0014-2999(93)90424-g.
4
Regulation of high- and low-affinity [3H]imipramine recognition sites in rat brain by chronic treatment with antidepressants.抗抑郁药长期治疗对大鼠脑中高亲和力和低亲和力[³H]丙咪嗪识别位点的调节作用。
Eur J Pharmacol. 1987 Jun 19;138(2):159-68. doi: 10.1016/0014-2999(87)90429-8.
5
Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.大鼠额叶皮质中γ-氨基丁酸（GABA）B结合位点的上调：不同类别的抗抑郁药重复给药和电休克的共同作用。
J Pharmacol Exp Ther. 1985 Oct;235(1):191-9.
6
Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.5-HT2和5-HT3受体在小鼠强迫游泳试验中抗抑郁药活性中的部分作用。
Eur J Pharmacol. 1997 May 1;325(2-3):129-35. doi: 10.1016/s0014-2999(97)00115-5.
7
Effect of long-term administration of antidepressant drugs on the 5-HT3 receptors that enhance the electrically evoked release of [3H]noradrenaline in the rat hippocampus.长期服用抗抑郁药物对大鼠海马体中增强电诱发[3H]去甲肾上腺素释放的5-HT3受体的影响。
Eur J Pharmacol. 1994 Dec 12;271(1):121-9. doi: 10.1016/0014-2999(94)90272-0.
8
Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain.5-羟色胺摄取抑制剂氟西汀和西酞普兰重复治疗对大鼠脑内5-羟色胺1A和5-羟色胺2受体的影响。
J Psychiatry Neurosci. 1994 Jan;19(1):63-7.
9
Repeated treatment with antidepressant drugs does not affect the benzodiazepine receptors in preincubated membrane preparations from mouse and rat brain.
Pharmacol Biochem Behav. 1987 Jan;26(1):35-6. doi: 10.1016/0091-3057(87)90529-6.
10
Effects of age and of chronic antidepressant treatment on [3H]tryptamine and [3H]dihydroalprenolol binding to rat cortical membranes.年龄及慢性抗抑郁药治疗对[3H]色胺和[3H]二氢阿普洛尔与大鼠皮质膜结合的影响。
Cell Mol Neurobiol. 1993 Feb;13(1):3-13. doi: 10.1007/BF00712985.

引用本文的文献

1
Case Report: Treatment of Kratom Use Disorder With a Classical Tricyclic Antidepressant.病例报告：使用经典三环类抗抑郁药治疗 kratom 使用障碍。
Front Psychiatry. 2021 Mar 31;12:640218. doi: 10.3389/fpsyt.2021.640218. eCollection 2021.
2
Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy.5-羟色胺能系统对自杀行为的调制：将临床前数据与临床实践和心理治疗相结合。
Exp Brain Res. 2013 Oct;230(4):605-24. doi: 10.1007/s00221-013-3669-z. Epub 2013 Aug 23.
3
Serotonin2A receptor binding potential in people with aggressive and violent behaviour.具有攻击性和暴力行为人群中血清素2A受体结合潜力
J Psychiatry Neurosci. 2008 Nov;33(6):499-508.
4
Cortical 5-hydroxytryptamine2A-receptor mediated excitatory synaptic currents in the rat following repeated daily fluoxetine administration.每日重复给予氟西汀后大鼠皮质5-羟色胺2A受体介导的兴奋性突触电流
Neurosci Lett. 2008 Jun 27;438(3):312-6. doi: 10.1016/j.neulet.2008.04.068. Epub 2008 Apr 24.
5
Tandem regulation of phosphoinositide signaling and acute behavioral effects induced by antidepressant agents in rats.大鼠中磷酸肌醇信号传导的串联调节及抗抑郁药诱导的急性行为效应
Psychopharmacology (Berl). 2007 Aug;193(2):271-82. doi: 10.1007/s00213-007-0784-1. Epub 2007 Apr 15.
6
Imaging the serotonin transporter during major depressive disorder and antidepressant treatment.重度抑郁症及抗抑郁治疗期间血清素转运体的成像研究
J Psychiatry Neurosci. 2007 Mar;32(2):86-102.
7
The anatomy of co-morbid neuropsychiatric disorders based on cortico-limbic synaptic interactions.基于皮质-边缘突触相互作用的共病神经精神障碍解剖学
Neurotox Res. 2006 Oct;10(2):65-85. doi: 10.1007/BF03033236.
8
Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone.抗抑郁药可逆转皮质酮介导的脑源性神经营养因子表达降低：抗抑郁药和皮质酮对特定外显子的差异调节。
Neuroscience. 2006;139(3):1017-29. doi: 10.1016/j.neuroscience.2005.12.058. Epub 2006 Feb 24.
9
Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice.可乐定可增强反苯环丙胺、苯乙肼及两种类似物在小鼠强迫游泳试验中的作用。
J Psychiatry Neurosci. 2002 May;27(3):178-85.
10
Neurochemical and metabolic aspects of antidepressants: an overview.抗抑郁药的神经化学和代谢方面：综述
J Psychiatry Neurosci. 2000 Nov;25(5):481-96.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.一种用于估算单胺氧化酶的灵敏且特异的检测方法。
Biochem Pharmacol. 1963 Dec;12:1439-41. doi: 10.1016/0006-2952(63)90215-6.
3
Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI).长期使用抗抑郁药氟西汀和地昔帕明进行治疗，可增强内分泌对血清素激动剂6-氯-2-[1-哌嗪基]-吡嗪（MK-212）和（±）-1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷盐酸盐（DOI）的反应。
J Pharmacol Exp Ther. 1993 Aug;266(2):836-44.
4
Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors.坦度螺酮和丙咪嗪长期治疗对5-羟色胺介导的行为反应及单胺受体的影响。
Neuropharmacology. 1993 Jun;32(6):561-73. doi: 10.1016/0028-3908(93)90052-5.
5
Evidence that chronic administration of paroxetine or fluoxetine enhances 5-HT2 receptor function in the brain of the guinea pig.
Neuropharmacology. 1993 Mar;32(3):249-56. doi: 10.1016/0028-3908(93)90108-f.
6
Is there action beyond receptors?受体之外还有其他作用吗？
J Psychiatry Neurosci. 1993 Mar;18(2):57-9.
7
A proposed new nomenclature for 5-HT receptors.一种关于5-羟色胺受体的新命名提议。
Trends Pharmacol Sci. 1993 Jun;14(6):233-6. doi: 10.1016/0165-6147(93)90016-d.
8
Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin.应激及抗抑郁药对海马和皮质5-羟色胺1A及5-羟色胺2受体与5-羟色胺转运位点的影响。
Brain Res. 1993 Jun 25;615(1):87-94. doi: 10.1016/0006-8993(93)91117-b.
9
Chronic antidepressant drug treatment attenuates motor-suppressant effects of apomorphine without changing [3H]GBR 12935 binding.
Eur J Pharmacol. 1993 Nov 9;249(2):125-31. doi: 10.1016/0014-2999(93)90424-g.
10
Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study.慢性氟西汀治疗上调大鼠脑中5-羟色胺摄取位点和5-羟色胺2受体：一项放射自显影研究。
Synapse. 1993 Aug;14(4):324-31. doi: 10.1002/syn.890140410.