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佐剂诱导的自身免疫/炎症综合征（ASIA），伴肾脏损害和皮肤钙质沉着：一例报告及文献综述

The Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA), Associated with Renal Compromise and Cutaneous Calcinosis: A Case Report and Literature Review.

作者信息

Betancur Henao Cristian, Rifaldo Juan Guillermo, Vicente-Pérez Rafael, Martinez-Avila Maria Cristina, Daza-Arnedo Rodrigo, Rico-Fontalvo Jorge

机构信息

Internal Medicine Department, Universidad Cooperativa de Colombia, Medellín, Colombia.

Division of Nephrology, San Juan de Dios Hospital, Santa Fe de Antioquia, Antioquia, Colombia.

出版信息

Case Rep Nephrol. 2024 May 14;2024:7524714. doi: 10.1155/2024/7524714. eCollection 2024.

DOI:10.1155/2024/7524714
PMID:38774402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11108691/
Abstract

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 to provide a more precise syndromic characterization of clinical manifestations observed in patients exposed to adjuvant substances such as biopolymers and silicone, among others. The clinical spectrum of this entity is variable, ranging from local involvement to potentially fatal immune-mediated systemic involvement. The interest in ASIA has grown in recent years, reinforcing diagnostic criteria and deepening the understanding of its pathophysiological behavior. This case report highlights a distinct range of clinical symptoms, such as general symptoms, advanced-stage chronic kidney disease, persistent hypercalcemia with suppressed parathyroid hormone (PTH), bilateral nephrocalcinosis, cutaneous calcinosis, and the presence of positive autoantibodies, emphasizing the significance of understanding this condition.

摘要

佐剂诱导的自身免疫/炎症综合征（ASIA）于2011年首次被提出，旨在更精确地对接触生物聚合物和硅酮等佐剂物质的患者中观察到的临床表现进行综合征特征描述。该病症的临床谱具有多样性，从局部受累到可能致命的免疫介导的全身受累。近年来，对ASIA的关注度不断提高，强化了诊断标准并加深了对其病理生理行为的理解。本病例报告突出了一系列独特的临床症状，如全身症状、晚期慢性肾病、甲状旁腺激素（PTH）受抑制的持续性高钙血症、双侧肾钙质沉着症、皮肤钙质沉着症以及自身抗体阳性，强调了认识这种病症的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ef/11108691/78112c03eb8b/CRIN2024-7524714.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ef/11108691/78112c03eb8b/CRIN2024-7524714.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ef/11108691/78112c03eb8b/CRIN2024-7524714.001.jpg

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本文引用的文献

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Cutaneous and Ganglion Sarcoidosis Induced by Polycaprolactone Facial Filler: A New Expression of ASIA Syndrome?聚己内酯面部填充剂诱发的皮肤和神经节结节病：亚洲综合征的一种新表现？
Eur J Case Rep Intern Med. 2021 Jun 9;8(7):002652. doi: 10.12890/2021_002652. eCollection 2021.
2
Classical Examples of the Concept of the ASIA Syndrome.经典的 ASIA 综合征概念示例。
Biomolecules. 2020 Oct 12;10(10):1436. doi: 10.3390/biom10101436.
3
The ASIA syndrome: basic concepts.亚洲综合征：基本概念。
Mediterr J Rheumatol. 2017 Jun 27;28(2):64-69. doi: 10.31138/mjr.28.2.64. eCollection 2017 Jun.
4
Autoinflammatory/autoimmunity syndrome induced by adjuvants (ASIA; Shoenfeld's syndrome): A new flame.佐剂诱发的炎症/自身免疫综合征（ASIA；Shoenfeld 综合征）：新的热点。
Autoimmun Rev. 2018 Dec;17(12):1259-1264. doi: 10.1016/j.autrev.2018.07.003. Epub 2018 Oct 12.
5
ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review.硅注射后出现的亚洲综合征、皮肤钙质沉着和慢性肾病。基于病例的综述。
Immunol Res. 2016 Dec;64(5-6):1142-1149. doi: 10.1007/s12026-016-8871-1.
6
Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld's syndrome).佐剂诱导的自身免疫综合征（肖费尔德综合征）的严重表现
Immunol Res. 2017 Feb;65(1):8-16. doi: 10.1007/s12026-016-8811-0.
7
ASIA or Shoenfeld's syndrome--an autoimmune syndrome induced by adjuvants.ASIA或肖费尔德综合征——一种由佐剂诱导的自身免疫综合征。
Rom J Intern Med. 2013 Jul-Dec;51(3-4):131-4.
8
Women with silicone breast implants and unexplained systemic symptoms: a descriptive cohort study.患有硅胶乳房植入物且有不明原因全身症状的女性：一项描述性队列研究。
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Aesthetic Plast Surg. 2014 Feb;38(1):95-99. doi: 10.1007/s00266-013-0167-4. Epub 2013 Nov 27.
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