Department of Urology, The National Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, China.
J Cell Biochem. 2019 Apr;120(4):6395-6401. doi: 10.1002/jcb.27926. Epub 2018 Oct 14.
The prognosis of patients with prostate cancer (PCa) remains poor.
GSE16560, GSE32448, GSE79957, GSE17951, and TCGA-PRAD were reanalyzed to evaluate the expression of homeobox B7 (HOXB7) between PCa tissues and normal prostate tissues and to characterize the correlation between the expression of HOXB7 and the clinicopathological features of patients with PCa. Gene set enrichment analysis was conducted to investigate the mechanisms.
HOXB7 was upregulated in PCa tissues (P = 0.0005). Both the univariate and multivariate analyses demonstrated that the expression of HOXB7 was correlated with the Gleason score and TNM staging of patients with PCa. The Gleason score and TNM staging were higher in the HOXB7 high expression group. The overall survival (hazard ratio [HR] = 0.632; 95% confidence interval [CI]: 0.4773-0.8369; P = 0.0014) and progression-free survival (HR = 0.544; 95% CI: 0.3157-0.9373; P = 0.0283) favored patients with PCa in HOXB7 low expression group over those in HOXB7 high expression group. PCa samples in HOXB7 low expression group were enriched in gene sets associated with the epithelial mesenchymal transition, apical junction, angiogenesis, ultraviolet response, and hypoxia.
HOXB7 might be an independent prognostic factor of patients with PCa.
前列腺癌（PCa）患者的预后仍然较差。
重新分析 GSE16560、GSE32448、GSE79957、GSE17951 和 TCGA-PRAD，以评估 PCa 组织和正常前列腺组织中同源盒 B7（HOXB7）的表达，并描述 HOXB7 表达与 PCa 患者临床病理特征的相关性。进行基因集富集分析以探讨其机制。
HOXB7 在 PCa 组织中上调（P=0.0005）。单因素和多因素分析均表明，HOXB7 的表达与 PCa 患者的 Gleason 评分和 TNM 分期相关。HOXB7 高表达组的 Gleason 评分和 TNM 分期更高。HOXB7 低表达组患者的总生存（风险比[HR]=0.632；95%置信区间[CI]：0.4773-0.8369；P=0.0014）和无进展生存（HR=0.544；95%CI：0.3157-0.9373；P=0.0283）均优于 HOXB7 高表达组。HOXB7 低表达组的 PCa 样本富集了与上皮间质转化、顶端连接、血管生成、紫外线反应和缺氧相关的基因集。
HOXB7 可能是 PCa 患者的一个独立预后因素。
