Stenzel-Poore M P, Hallick L M, Fendrick J L, Neuburg M, Storrs F J, Hanifin J M
Sex Transm Dis. 1987 Jan-Mar;14(1):17-22. doi: 10.1097/00007435-198701000-00004.
Nine women and eight men with a history of genital herpes had cultures taken for 60 consecutive days to assess the frequency and duration of viral shedding in the absence of symptoms. Daily self-obtained specimens (cervical-vaginal swabs from women and urethral swabs from men) were submitted for viral isolation. Five of 972 samples were found to contain infectious virus; two of the positive specimens correlated with overt disease. The other three positive cultures, two from the same individual, were not clearly associated with a genital infection. Thus, the overall frequency of asymptomatic viral shedding was 0.31% and occurred in two of 17 individuals. It is concluded that prolonged continuous sampling may be necessary to assess the risk of asymptomatic shedding. Infectious virus was not present in the genital secretions of most individuals (15 of 17) in the absence of a lesion, even when cultured on a daily basis for 60 days.
9名有生殖器疱疹病史的女性和8名有生殖器疱疹病史的男性连续60天进行培养，以评估无症状情况下病毒脱落的频率和持续时间。每天自行采集的标本（女性的宫颈-阴道拭子和男性的尿道拭子）用于病毒分离。972份样本中有5份被发现含有传染性病毒；其中2份阳性标本与明显疾病相关。另外3份阳性培养物，其中2份来自同一个体，与生殖器感染没有明显关联。因此，无症状病毒脱落的总体频率为0.31%，17人中有2人出现这种情况。得出的结论是，可能需要长时间连续采样来评估无症状脱落的风险。即使每天培养60天，大多数个体（17人中有15人）在无病变时生殖器分泌物中也不存在传染性病毒。
