Molecular Biology Unit, Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Cell Biochem Funct. 2018 Dec;36(8):408-412. doi: 10.1002/cbf.3360. Epub 2018 Oct 14.
Genomic regulation and functional significance of PVT-1 gene locus, in the MYC-driven cancers, has remained enigmatic ever since its discovery. With the present study, an attempt is made to establish that cellular AATF genome encoded miR-2909 RNomics pathway involving crucial genes coding for KLF4, Deptor, mTORC1, STAT3, and p53 has the inherent capacity to ensure sustained co-amplification of PVT-1 gene locus together with c-Myc gene. Based upon these results, we propose that miR-2909 RNomics pathway may play a crucial role in the regulation of tumorigenic PVT-1 gene locus.
基因组调控和 PVT-1 基因座在 MYC 驱动的癌症中的功能意义，自从其发现以来一直是个谜。通过本研究，试图确定细胞 AATF 基因组编码的 miR-2909 RNA 通路涉及编码 KLF4、Dep tor、mTORC1、STAT3 和 p53 的关键基因，具有确保 PVT-1 基因座与 c-Myc 基因持续共扩增的内在能力。基于这些结果，我们提出 miR-2909 RNA 通路可能在调节肿瘤发生的 PVT-1 基因座中发挥关键作用。
