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线粒体解偶联蛋白（UCP2）基因表达受miR - 2909调控。

Mitochondrial uncoupling protein (UCP2) gene expression is regulated by miR-2909.

作者信息

Kaul Deepak, Sharma S, Garg A

机构信息

Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.

Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.

出版信息

Blood Cells Mol Dis. 2015 Jun;55(1):89-93. doi: 10.1016/j.bcmd.2015.05.001. Epub 2015 May 5.

DOI:10.1016/j.bcmd.2015.05.001
PMID:25976474
Abstract

Reversible decoupling of glycolysis from aerobic-respiration has been widely recognized to be a crucial step in tailoring immune response by the human cells. In this context, the study reported here revealed for the first time that cooperativity between Apoptosis Antagonizing Transcription Factor (AATF) mRNA and miR-2909 within cellular AATF RNome ensures the regulation of mitochondrial uncoupling protein 2 (UCP2) expression in a cyclic fashion and this phenomenon is substantiated when the immune cells face high glucose threat.

摘要

糖酵解与有氧呼吸的可逆解偶联已被广泛认为是人体细胞调整免疫反应的关键步骤。在此背景下，本文报道的研究首次揭示，细胞AATF核糖核酸组内凋亡拮抗转录因子（AATF）mRNA与miR-2909之间的协同作用确保了线粒体解偶联蛋白2（UCP2）表达的周期性调节，并且当免疫细胞面临高葡萄糖威胁时，这一现象得到了证实。

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