Molecular Biology Unit, Experimental Medicine & Biotechnology Department, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.
Mol Cell Biochem. 2019 Jan;451(1-2):37-42. doi: 10.1007/s11010-018-3390-0. Epub 2018 Jun 20.
Cross-talk between coding RNAs and regulatory non-coding microRNAs, within human genome, has provided compelling evidence for the existence of flexible checkpoint control of T-Cell activation. The present study attempts to demonstrate that the interplay between miR-2909 and its effector KLF4 gene has the inherent capacity to regulate genes coding for CTLA4, CD28, CD40, CD134, PDL1, CD80, CD86, IL-6 and IL-10 within normal human peripheral blood mononuclear cells (PBMCs). Based upon these findings, we propose a pathway that links miR-2909 RNomics with the genes coding for immune checkpoint regulators required for the maintenance of immune homeostasis.
编码 RNA 与人类基因组内的调控性非编码 microRNA 之间的串扰，为 T 细胞激活的灵活检查点控制的存在提供了有力证据。本研究试图证明 miR-2909 与其效应物 KLF4 基因之间的相互作用具有调节编码 CTLA4、CD28、CD40、CD134、PDL1、CD80、CD86、IL-6 和 IL-10 的基因的内在能力，这些基因位于正常人外周血单个核细胞（PBMCs）中。基于这些发现，我们提出了一条途径，将 miR-2909 转录组学与编码免疫检查点调节剂的基因联系起来，这些基因对于维持免疫稳态是必需的。
