评估一种透明颅骨植入物作为脑血流成像的永久性窗口。
Evaluation of a transparent cranial implant as a permanent window for cerebral blood flow imaging.
作者信息
Davoodzadeh Nami, Cano-Velázquez Mildred S, Halaney David L, Jonak Carrie R, Binder Devin K, Aguilar Guillermo
机构信息
Department of Mechanical Engineering, University of California, Riverside, CA, USA.
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, México.
出版信息
Biomed Opt Express. 2018 Sep 17;9(10):4879-4892. doi: 10.1364/BOE.9.004879. eCollection 2018 Oct 1.
Abstract
Laser speckle imaging (LSI) of mouse cerebral blood flow was compared through a transparent nanocrystalline yttria-stabilized zirconia (nc-YSZ) cranial implant over time (at days 0, 14, and 28, n = 3 mice), and vs. LSI through native skull (at day 60, n = 1 mouse). The average sharpness of imaged vessels was found to remain stable, with relative change in sharpness under 7.69% ± 1.2% over 28 days. Through-implant images of vessels at day 60 appeared sharper and smaller on average, with microvessels clearly visible, compared to through-skull images where vessels appeared blurred and distorted. These results suggest that long-term imaging through this implant is feasible.
摘要
通过透明的纳米晶氧化钇稳定氧化锆（nc-YSZ）颅骨植入物，对小鼠脑血流的激光散斑成像（LSI）随时间（第0、14和28天，n = 3只小鼠）进行了比较，并与通过天然颅骨的LSI（第60天，n = 1只小鼠）进行了比较。发现成像血管的平均清晰度保持稳定，在28天内清晰度的相对变化低于7.69%±1.2%。与通过颅骨的图像相比，第60天通过植入物的血管图像平均显得更清晰、更小，微血管清晰可见，而通过颅骨的血管图像则显得模糊和扭曲。这些结果表明，通过这种植入物进行长期成像具有可行性。
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