局部应用干扰素α-2b治疗广泛的眼表鳞状上皮肿瘤
Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b.
作者信息
Patel Hershel, Jeang Lauren J, Shah Ankit, Espana Edgar M, Margo Curtis E
机构信息
Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Department of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, USA.
出版信息
Ocul Oncol Pathol. 2018 Sep;4(5):298-303. doi: 10.1159/000486339. Epub 2018 Feb 13.
PURPOSE
To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone.
CASES
Two patients with 360 degrees of limbal involvement.
RESULTS
Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease. The patients had complete response to therapy.
CONCLUSION
Widespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.
目的
强调在考虑单独使用局部干扰素α-2b时对眼表鳞状上皮肿瘤进行分期的重要性。
病例
两名患者均有360度的角膜缘受累。
结果
两名结膜原位鳞状细胞癌且整个角膜缘有临床受累的患者接受了局部干扰素α-2b治疗。全面检查和多次活检排除了浸润性疾病。患者对治疗有完全反应。
结论
累及整个角膜缘的广泛上皮内鳞状上皮肿瘤可用局部治疗成功治疗。活检在排除浸润性疾病方面起作用。干扰素α-2b是首选药物，因为其耐受性良好。由于复发的长期风险未知，适当的监测至关重要。
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