Hartry Ann, Aldhouse Natalie V J, Al-Zubeidi Tamara, Sanon Myrlene, Stefanacci Richard G, Knight Sarah L
Lundbeck, Deerfield, IL, USA.
DRG Abacus, Manchester, UK.
Alzheimers Dement (Amst). 2018 Aug 10;10:498-508. doi: 10.1016/j.dadm.2018.07.006. eCollection 2018.
This study aims to evaluate the conceptual relevance of four measures of disease activity in patients with mild/mild-moderate Alzheimer's disease (AD): (1) the Alzheimer's Disease Assessment Scale-Cognitive Subscale; (2) the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory; (3) the Neuropsychiatry Inventory; and (4) the Dependence Scale.
A conceptual model depicting patient experience of mild AD was developed via literature review; concepts were compared with the items of the four measures. Relevance of the concepts included in the four measures was evaluated by patients with mild AD in a survey and follow-up interviews.
The four measures assessed few of the symptoms/impacts of mild AD identified within the literature. Measured items addressing emotional impacts were deemed most relevant by participants but were included in the measures only superficially.
The four assessment measures do not appear to capture the concepts most relevant to/important to patients with mild/mild-moderate AD.
本研究旨在评估四种疾病活动测量方法对于轻度/轻度至中度阿尔茨海默病（AD）患者的概念相关性：（1）阿尔茨海默病评估量表 - 认知分量表；（2）阿尔茨海默病协作研究 - 日常生活活动量表；（3）神经精神科问卷；以及（4）依赖量表。
通过文献综述构建了一个描述轻度AD患者体验的概念模型；将这些概念与四种测量方法的项目进行比较。轻度AD患者在一项调查和后续访谈中对四种测量方法中包含的概念的相关性进行了评估。
这四种测量方法评估的文献中确定的轻度AD的症状/影响很少。参与者认为涉及情绪影响的测量项目最相关，但这些项目仅在测量方法中被表面地包含。
这四种评估方法似乎并未涵盖与轻度/轻度至中度AD患者最相关/最重要的概念。
