几种基于透明质酸的凝胶的流变学性质：一项比较研究。

Rheological Properties of Several Hyaluronic Acid-Based Gels: A Comparative Study.

作者信息

Micheels Patrick, Eng Martinien Obamba

出版信息

J Drugs Dermatol. 2018 Sep 1;17(9):948-954.

Abstract

BACKGROUND

Adding lidocaine to hyaluronic acid (HA)-based gels appeared to modify their rheological properties, in the view of the first author.

OBJECTIVE

This paper sought to compare the rheological properties of three CE-marked and FDA-approved gels, administered with and without lidocaine, along with two other newly FDA-approved gels.

METHODS

The tested gels were as follows: NASHA® Restylane® with and without lidocaine; CPM®; Belotero® Balance with and without lidocaine; 3-D Matrix®; Surgiderm® 30XP (without lidocaine) and Juvederm® Ultra 3- Juvederm® Ultra Plus XC (with lidocaine); Preserved Network® RHA®2 (with lidocaine); Vycross® Volbella® (with lidocaine). For rheological analyses, viscoelastic data were collected with plate-plate geometry of 25mm, temperature regulated by a Peltier-effect plate, and the following assessed: Strain sweep from 0.01% to 3000% strain at 1Hz over frequency sweep from 0.1 to 100 Hz.

RESULTS

NASHA Restylane gels with and without lidocaine exhibited similar viscoelastic characteristics, with very similar tan δ values, but the elastic modulus G' proved significantly higher when the gel was injected with lidocaine vs without. 3D-Matrix Surgiderm 30XP gel without lidocaine and Juvéderm Ultra 3 with lidocaine exhibited similar viscoelastic characteristics, as well as tan δ values, yet the elastic modulus G' of Surgiderm 30XP proved significantly higher than that of Juvederm Ultra 3-Juvederm Ultra Plus XC. CPM Belotero Balance gels with and without lidocaine exhibited similar G' and G'' values. tan δ was somewhat higher when the gel was administered without lidocaine. VYCROSS Volbella gel exhibited a higher elastic modulus G' than the other Allergan gels, roughly nearing the NASHA gel values. Preserved Network RHA 2 gel exhibited values that were close to its partially cohesive "competitors", except for Vycross.

CONCLUSION

Adding lidocaine to HA gels does modify their rheological properties yet this, to a variable extent depending on the product. J Drugs Dermatol. 2018;17(9):948-954.

摘要

背景

第一作者认为，在基于透明质酸（HA）的凝胶中添加利多卡因似乎会改变其流变学特性。

目的

本文旨在比较三种获得CE标志且经美国食品药品监督管理局（FDA）批准的凝胶（分别添加和未添加利多卡因）以及另外两种新获得FDA批准的凝胶的流变学特性。

方法

所测试的凝胶如下：含和不含利多卡因的NASHA®瑞蓝®；CPM®；含和不含利多卡因的贝洛特罗®平衡；3-D基质®；舒颜萃®30XP（不含利多卡因）和乔雅登®极致3 - 乔雅登®极致加强版XC（含利多卡因）；Preserved Network®RHA®2（含利多卡因）；Vycross®柔致®（含利多卡因）。对于流变学分析，使用25mm的平板几何形状收集粘弹性数据，通过珀耳帖效应板调节温度，并进行以下评估：在1Hz频率下从0.01%到3000%应变的应变扫描以及从0.1到100Hz的频率扫描。

结果

含和不含利多卡因的NASHA瑞蓝凝胶表现出相似的粘弹性特征，损耗角正切（tan δ）值非常相似，但注射利多卡因的凝胶的弹性模量G'明显高于未注射的。不含利多卡因的3D - 基质舒颜萃30XP凝胶和含利多卡因的乔雅登极致3表现出相似的粘弹性特征以及tan δ值，但舒颜萃30XP的弹性模量G'明显高于乔雅登极致3 - 乔雅登极致加强版XC。含和不含利多卡因的CPM贝洛特罗平衡凝胶表现出相似的G'和G''值。未注射利多卡因时tan δ略高。VYCROSS柔致凝胶的弹性模量G'高于其他艾尔建公司的凝胶，大致接近NASHA凝胶的值。Preserved Network RHA 2凝胶表现出的值接近其部分具有粘性的“竞争对手”，Vycross除外。