Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway.
J Alzheimers Dis. 2018;66(2):825-833. doi: 10.3233/JAD-180768.
Physical activity (PA) is associated with a decreased dementia risk, whereas psychological distress (distress) is linked to an increased dementia risk.
We investigated independent and joint associations of midlife moderate-to-vigorous PA (MVPA) and distress with incident dementia.
Our study comprised 28,916 participants aged 30-60 years from the Nord-Trøndelag Health Study (HUNT1, 1984-1986). Data on MVPA and distress from HUNT1 was linked to the Health and Memory Study in Nord-Trøndelag for dementia case identification. Participants were followed from 1995 until 2011. We used adjusted Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI).
In fully adjusted analyses, MVPA was associated with a reduced dementia risk (HR 0.81, 95% CI 0.62-1.06), compared to no MVPA. Distress was associated with an increased dementia risk (HR 1.30, 95% CI 0.99-1.70). Compared to distressed participants not taking part in MVPA, non-distressed no-MVPA participants had a reduced dementia risk (HR 0.72, 95% CI 0.54-0.96). The same applied to distressed MVPA participants (HR 0.50, 95% CI 0.22-1.14), and non-distressed MVPA participants (HR 0.63, 95% CI 0.44-0.90). Our results indicated an additive interaction between MVPA and distress on dementia risk.
Our results suggest that midlife MVPA reduces risk of incident dementia among both distressed and non-distressed individuals.
身体活动（PA）与痴呆风险降低有关，而心理困扰（distress）与痴呆风险增加有关。
我们研究了中年中度至剧烈体力活动（MVPA）和困扰与痴呆发病的独立和联合关联。
我们的研究包括来自诺德兰特伦德拉格健康研究（HUNT1，1984-1986 年）的 28916 名 30-60 岁的参与者。HUNT1 中的 MVPA 和困扰数据与诺德兰特伦德拉格健康与记忆研究相关联，以确定痴呆病例。参与者从 1995 年随访至 2011 年。我们使用调整后的 Cox 回归模型来估计风险比（HR）和 95%置信区间（95%CI）。
在完全调整后的分析中，与没有 MVPA 相比，MVPA 与痴呆风险降低相关（HR 0.81，95%CI 0.62-1.06）。困扰与痴呆风险增加相关（HR 1.30，95%CI 0.99-1.70）。与不参加 MVPA 的困扰参与者相比，不困扰且不参加 MVPA 的参与者痴呆风险降低（HR 0.72，95%CI 0.54-0.96）。同样适用于困扰的 MVPA 参与者（HR 0.50，95%CI 0.22-1.14）和不困扰的 MVPA 参与者（HR 0.63，95%CI 0.44-0.90）。我们的结果表明，MVPA 和困扰之间存在痴呆风险的附加交互作用。
我们的研究结果表明，中年 MVPA 降低了有困扰和无困扰个体发生痴呆的风险。
