使用同心球模型研究肺肺泡和气道表面液体的光散射。
Light scattering by pulmonary alveoli and airway surface liquid using a concentric sphere model.
出版信息
Opt Lett. 2018 Oct 15;43(20):5001-5004. doi: 10.1364/OL.43.005001.
Abstract
We employ a concentric sphere Mie scattering model to describe light scattering by pulmonary alveoli and airway surface liquid (ASL). Using this layered sphere model, we compare alveolar scattering at different points along the respiratory cycle and observe the effect of ASL thickness on light scattering in the lung. We have also extrapolated the model to investigate alveolar scattering in various animal models of pulmonary disease. This model of pulmonary light scattering can estimate in vivo optical properties for normal and pathological states, potentially aiding the design of optical systems for diagnosis and investigation of pulmonary pathologies.
摘要
我们采用同心球 Mie 散射模型来描述肺肺泡和气道表面液体 (ASL) 的光散射。使用这种分层球模型，我们比较了呼吸周期不同点的肺泡散射，并观察了 ASL 厚度对肺部光散射的影响。我们还将该模型外推到研究各种肺部疾病动物模型中的肺泡散射。这种肺部光散射模型可以估计正常和病理状态下的体内光学特性，可能有助于设计用于诊断和研究肺部疾病的光学系统。
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