新型脂肽抗生素LY146032对革兰氏阳性球菌的体外活性
In vitro activity of LY146032, a new lipopeptide antibiotic, against gram-positive cocci.
作者信息
Verbist L
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):340-2. doi: 10.1128/AAC.31.2.340.
Abstract
The activity of LY146032, a new lipopeptide antibiotic, was compared in vitro with those of vancomycin, oxacillin, and ampicillin against 261 staphylococcal and 154 streptococcal isolates. The MICs of LY146032 and vancomycin were similar, but the bactericidal activity and killing kinetics of LY146032 were more pronounced.
摘要
将一种新型脂肽抗生素LY146032的活性与万古霉素、苯唑西林和氨苄西林在体外对261株葡萄球菌和154株链球菌分离株的活性进行了比较。LY146032和万古霉素的最低抑菌浓度相似，但LY146032的杀菌活性和杀菌动力学更为显著。
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