新型脂肽类抗菌药物LY146032（达托霉素）的体外活性比较

Comparative in vitro activity of LY146032 (daptomycin), a new lipopeptide antimicrobial.

作者信息

Hodinka R L, Jack-Wait K, Wannamaker N, Walden T P, Gilligan P H

出版信息

Eur J Clin Microbiol. 1987 Feb;6(1):100-3. doi: 10.1007/BF02097211.

DOI:10.1007/BF02097211

Abstract

The in vitro activity of LY146032, a new cyclic lipopeptide antibiotic, was compared with those of vancomycin, teicoplanin, and either oxacillin or ampicillin by determining agar dilution MIC values for 304 clinical gram-positive isolates. LY146032 had superior in vitro activity against oxacillin-resistant staphylococci when compared to vancomycin or teicoplanin. Against oxacillin-sensitive staphylococci, group JK-diphtheroids, streptococci, Listeria monocytogenes and Clostridium difficile, LY146032 was equally or less active than vancomycin, teicoplanin, or the penicillins tested. When tested by macrobroth dilution MIC/MBC, LY146032 showed good bactericidal activity against all organisms with the exception of Clostridium difficile.

摘要

通过测定304株临床革兰氏阳性分离菌的琼脂稀释法最低抑菌浓度（MIC）值，将新型环脂肽抗生素LY146032的体外活性与万古霉素、替考拉宁以及苯唑西林或氨苄西林进行了比较。与万古霉素或替考拉宁相比，LY146032对耐苯唑西林葡萄球菌具有更强的体外活性。对于苯唑西林敏感葡萄球菌、JK组类白喉杆菌、链球菌、单核细胞增生李斯特菌和艰难梭菌，LY146032的活性与万古霉素、替考拉宁或所测试的青霉素相当或更低。当通过微量肉汤稀释法测定MIC/MBC时，LY146032对除艰难梭菌外的所有微生物均显示出良好的杀菌活性。