Munyenyembe Alinane U, Gausi Kamunkhwala, Nyirenda Tonney S, Hiestand Jasmin, Mallewa Jane, Mandala Wilson L
Malawi-Liverpool Wellcome Trust, Malaria Immunology Department, Blantyre, Malawi,
Pathology Department, College of Medicine, Blantyre, Malawi.
J Blood Med. 2018 Oct 4;9:153-162. doi: 10.2147/JBM.S172869. eCollection 2018.
Although malaria and HIV infections independently affect the electrolyte and hematologic profiles, little is known of how these profiles are affected in individuals coinfected with malaria and HIV. We therefore conducted this study to investigate the electrolyte and hematologic profiles of Malawian adults presenting with either uncomplicated malaria (UM), severe malaria (SM), and those presenting with HIV and UM or HIV and SM.
Study participants were recruited at Queen Elizabeth Central Hospital, and malaria infection was confirmed by rapid diagnostic test and malaria slides, and full blood count, HIV, and wet chemistries were analyzed.
Sodium, potassium, calcium, and chloride levels of all 4 study groups were similar to those of healthy controls. Both HIV-infected groups (UM and SM) had lower red blood cell counts and lower hemoglobin concentration than the reference range. Platelet counts were lower in both HIV-uninfected SM cases (64×10/L) and in the HIV-infected SM cases (66×10/L) compared to the reference range (115-290×10/L). HIV- UM cases had higher proportion and absolute counts of neutrophils and white blood cell counts compared to the HIV+ UM cases.
HIV infection did not affect the electrolyte profile of Malawian adults presenting with UM or SM but had an effect on red blood cells, Hb concentration, neutrophils, and platelet counts.
尽管疟疾和艾滋病毒感染分别会影响电解质和血液学指标，但对于同时感染疟疾和艾滋病毒的个体，这些指标如何受到影响却知之甚少。因此，我们开展了这项研究，以调查出现非重症疟疾（UM）、重症疟疾（SM）的马拉维成年人以及同时感染艾滋病毒和UM或艾滋病毒和SM的个体的电解质和血液学指标。
在伊丽莎白女王中央医院招募研究参与者，通过快速诊断检测和疟原虫玻片检查确认疟疾感染情况，并对全血细胞计数、艾滋病毒和生化指标进行分析。
所有4个研究组的钠、钾、钙和氯水平与健康对照组相似。两个感染艾滋病毒的组（UM和SM）的红细胞计数和血红蛋白浓度均低于参考范围。与参考范围（115 - 290×10⁹/L）相比，未感染艾滋病毒的SM病例（64×10⁹/L）和感染艾滋病毒的SM病例（66×10⁹/L）的血小板计数均较低。与艾滋病毒阳性的UM病例相比，艾滋病毒阴性的UM病例的中性粒细胞比例、绝对计数和白细胞计数更高。
艾滋病毒感染并未影响出现UM或SM的马拉维成年人的电解质指标，但对红细胞、血红蛋白浓度、中性粒细胞和血小板计数有影响。
