Université François Rabelais de Tours, Tours, France.
CNRS, GICC UMR 7292, Tours, France.
Front Immunol. 2018 Sep 28;9:2259. doi: 10.3389/fimmu.2018.02259. eCollection 2018.
The neonatal Fc receptor (FcRn) is responsible for the recycling and transcytosis of IgG and albumin. FcRn level was found altered in cancer tissues and implicated in tumor immunosurveillance and neoplastic cell growth. However, the consequences of FcRn down-regulation in the anti-tumor immune response are not fully elucidated. By using the B16F10 experimental lung metastasis model in an FcRn-deficient microenvironment (FcRn mice), we found lung metastasis associated with an abnormal natural killer (NK) cell phenotype. In FcRn mice, NK cells were immature, as shown by their surface marker profile and their decreased ability to degranulate and synthesize interferon γ after chemical and IL-2 or IL-12, IL-15 and IL-18 activation. These new findings support the critical role of FcRn downregulation in the tumor microenvironment in anti-tumor immunity, via NK cell maturation and activation.
新生儿 Fc 受体 (FcRn) 负责 IgG 和白蛋白的再循环和转胞吞作用。已经发现 FcRn 水平在肿瘤组织中发生改变，并与肿瘤免疫监视和肿瘤细胞生长有关。然而，FcRn 下调对抗肿瘤免疫反应的后果尚未完全阐明。通过使用 FcRn 缺陷微环境（FcRn 小鼠）中的 B16F10 实验性肺转移模型，我们发现与异常自然杀伤 (NK) 细胞表型相关的肺转移。在 FcRn 小鼠中，NK 细胞不成熟，表现为其表面标志物特征以及在化学和 IL-2 或 IL-12、IL-15 和 IL-18 激活后脱颗粒和合成干扰素 γ 的能力下降。这些新发现支持 FcRn 下调在肿瘤微环境中通过 NK 细胞成熟和激活在抗肿瘤免疫中的关键作用。
