Departamento de Ciencias de la Alimentación y Fisiología, Universidad de Navarra, Facultad de Farmacia y Nutrición, Pamplona, Spain.
IdiSNA- Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
J Sci Food Agric. 2019 Mar 30;99(5):2251-2258. doi: 10.1002/jsfa.9420. Epub 2018 Dec 14.
The bioaccessibility of bioactive compounds for functional food deserves evaluation. An in vitro gastrointestinal digestion model was applied to provide information about the extent of lipid hydrolysis, oxidative stability and bioaccessibility of algae oil (42% of docosahexaenoic acid; DHA), comparing three lipid delivery systems: bulk oil, soy protein stabilized O/W emulsion and carrageenan gelled emulsion.
Lipid digestion kinetics was slightly influenced by the delivery systems. Nevertheless, at the end of intestinal digestion, lipolysis in the three samples ranged between 49% and 52%, showing a partial oil digestion. Lipid oxidation, measured by malondialdehyde, was significantly lower (P < 0.01) in both emulsified oils after intestinal digestion compared to the bulk oil. Bioaccessibility of DHA was 58%, 71% and 84% for bulk oil, O/W emulsion and gelled emulsion, respectively.
These results suggest that both emulsified delivery systems used in the present study enhanced the solubilization of free fatty acids, in particular omega-3 fatty acids, and therefore their potential intestinal absorption. © 2018 Society of Chemical Industry.
对于功能性食品来说，生物活性化合物的生物利用度值得评估。本研究应用体外胃肠道消化模型，提供关于藻油（42%二十二碳六烯酸；DHA）的脂解程度、氧化稳定性和生物利用度的信息，比较了三种脂质传递系统：普通油、大豆蛋白稳定的 O/W 乳液和卡拉胶凝胶乳液。
脂质消化动力学受传递系统的轻微影响。然而，在肠内消化结束时，三种样品的脂解率在 49%到 52%之间，表明油部分消化。通过丙二醛测量的脂质氧化在肠内消化后两种乳化油中均显著低于普通油（P<0.01）。DHA 的生物利用度分别为普通油、O/W 乳液和凝胶乳液的 58%、71%和 84%。
本研究中使用的两种乳化传递系统均增强了游离脂肪酸的溶解能力，特别是 ω-3 脂肪酸，从而提高了其潜在的肠道吸收能力。© 2018 英国化学学会。
