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体外T辅助细胞的产生。III. 辅助细胞培养衍生因子与H-2主要组织相容性复合体I区编码的同种抗原相关。

Generation of T helper cells in vitro. III. Helper cell culture-derived factors are related to alloantigens coded for the I region of the H-2 major histocompatibility complex.

作者信息

McDougal J S, Cort S P, Gordon D S

出版信息

J Immunol. 1977 Dec;119(6):1933-7.

PMID:303255
Abstract

Thymocyte-macrophage cultures primed with carrier protein release an alloantigen-related factor that enhances the anti-hapten plaque-forming cell response of hapten-primed spleen cells in vitro. Use of immunoadsorbant columns made with a variety of alloantisera indicates that the relevant antigens in this system are coded for the the H-2 major histocompatibility locus in mice. The data indicate that in H-2d and H-2k strains the important genetic regions are in the I region between the K region and the I-C subregion and suggest, based on current understanding of Ia specificities, that the I-A subregion codes for these antigens.

摘要

用载体蛋白致敏的胸腺细胞-巨噬细胞培养物可释放一种同种抗原相关因子，该因子在体外可增强经半抗原致敏的脾细胞的抗半抗原空斑形成细胞反应。使用由多种同种抗血清制成的免疫吸附柱表明，该系统中的相关抗原由小鼠的H-2主要组织相容性位点编码。数据表明，在H-2d和H-2k品系中，重要的基因区域位于K区域和I-C亚区域之间的I区域，并且根据目前对Ia特异性的理解表明，I-A亚区域编码这些抗原。

相似文献

1
Generation of T helper cells in vitro. III. Helper cell culture-derived factors are related to alloantigens coded for the I region of the H-2 major histocompatibility complex.体外T辅助细胞的产生。III. 辅助细胞培养衍生因子与H-2主要组织相容性复合体I区编码的同种抗原相关。
J Immunol. 1977 Dec;119(6):1933-7.
2
H-2K/H-2D and Mls and I region-associated antigens stimulate helper factor(s) involved in the generation of cytotoxic T lymphocytes.H-2K/H-2D以及Mls和I区相关抗原刺激参与细胞毒性T淋巴细胞生成的辅助因子。
J Immunol. 1980 May;124(5):2378-83.
3
T cell-produced immunoglobulin binding factor (IBF) bears determinants coded for by the I region of the major histocompatibility complex and lacks allogeneic restriction.T细胞产生的免疫球蛋白结合因子（IBF）带有由主要组织相容性复合体I区编码的决定簇，且无同种异体限制性。
Eur J Immunol. 1979 Mar;9(3):237-42. doi: 10.1002/eji.1830090313.
4
Nature of macrophage-T cell interaction in secondary helper cell generation in vitro. Genetic restriction of macrophage-T cell interaction, which determines T-B genetic restriction.体外次级辅助性T细胞生成过程中巨噬细胞与T细胞相互作用的性质。巨噬细胞与T细胞相互作用的遗传限制，这决定了T细胞与B细胞的遗传限制。
Eur J Immunol. 1981 May;11(5):377-81. doi: 10.1002/eji.1830110506.
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The differentiation of cytotoxic T cells in vitro. II. Amplifying factor(s) produced in primary mixed lymphocyte cultures against K/D stimuli require the presence of Lyt 2+ cells but not Lyt 1+ cells.细胞毒性T细胞的体外分化。II. 针对K/D刺激在初次混合淋巴细胞培养物中产生的扩增因子需要Lyt 2+细胞存在，但不需要Lyt 1+细胞。
J Immunol. 1980 Jul;125(1):300-7.
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T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera.富含T淋巴细胞的小鼠腹腔渗出细胞。III. 用抗Ia抗血清抑制抗原诱导的T淋巴细胞增殖。
J Immunol. 1976 Aug;117(2):531-40.
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Cellular responses to murine alloantigens of the major histocompatibility complex: the role of cell subpopulations that express different quantities of H-2 associated antigenic markers.细胞对主要组织相容性复合体小鼠同种异体抗原的反应：表达不同数量H-2相关抗原标记的细胞亚群的作用。
Eur J Immunol. 1976 Mar;6(3):180-7. doi: 10.1002/eji.1830060308.
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Induction and characterization of minor histocompatibility antigens. Specific primary cytotoxic T lymphocyte responses in vitro.次要组织相容性抗原的诱导与特性。体外特异性原发性细胞毒性T淋巴细胞反应。
J Immunol. 1988 Feb 1;140(3):723-9.
9
Generation of T helper cells in vitro. IV. F1 T helper cells primed with antigen-pulsed parental macrophages are genetically restricted in their antigen-specific helper activity.体外T辅助细胞的产生。IV. 用抗原脉冲处理的亲代巨噬细胞致敏的F1 T辅助细胞在其抗原特异性辅助活性方面受到基因限制。
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Functional differentiation in the genetic control of murine T lymphocyte responses to human fibrinopeptide B.小鼠T淋巴细胞对人纤维蛋白肽B反应的遗传控制中的功能分化
J Immunol. 1983 Feb;130(2):637-43.

引用本文的文献

1
Partial characterization of murine and monkey helper factor to a streptococcal antigen.针对链球菌抗原的小鼠和猴辅助因子的部分特性分析。
Immunology. 1980 Nov;41(3):587-96.
2
Antigen B-specific helper factor from timothy grass pollen: isolation and partial characterization.梯牧草花粉中的抗原B特异性辅助因子：分离与部分特性鉴定
Immunology. 1981 Oct;44(2):373-9.
3
Antigen-specific T-cell factors.抗原特异性T细胞因子。
Immunology. 1980 Dec;41(4):759-87. doi: 10.1007/BF00199524.
4
Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.淋巴细胞调节分子的生化与生物学特性。I. 一类小鼠淋巴因子的纯化。
J Exp Med. 1979 Oct 1;150(4):849-61. doi: 10.1084/jem.150.4.849.