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抗原特异性T细胞因子。

Antigen-specific T-cell factors.

作者信息

Taussig M J

出版信息

Immunology. 1980 Dec;41(4):759-87. doi: 10.1007/BF00199524.

DOI:10.1007/BF00199524
PMID:6161877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458315/
Abstract

Antigen-specific T-cell factors are mediator molecules which are produced by helper and suppressor T cells and which can perform the function of those cells in an antigen-specific manner. They probably play an important part in immunoregulation. The major histocompatibility complex has a controlling influence on their structure and activity, while their antigen-recognition properties may be conferred by immunoglobulin V regions. Interest in the factors derives from three related areas of research, namely (i) the problem of T-cell recognition of antigen; (ii) the mechanisms of cellular interactions in antibody production and cell-mediated immunity; and (iii) the genetic control of immune responses. This review discusses the literature up to June 1980 on their production, structure, genetic restriction and mechanism of action.

摘要

抗原特异性T细胞因子是由辅助性T细胞和抑制性T细胞产生的介导分子，它们能够以抗原特异性方式发挥这些细胞的功能。它们可能在免疫调节中起重要作用。主要组织相容性复合体对其结构和活性具有控制作用，而其抗原识别特性可能由免疫球蛋白V区赋予。对这些因子的兴趣源于三个相关研究领域，即（i）T细胞对抗原的识别问题；（ii）抗体产生和细胞介导免疫中细胞相互作用的机制；以及（iii）免疫反应的遗传控制。本综述讨论了截至1980年6月关于它们的产生、结构、遗传限制和作用机制的文献。

相似文献

1
Antigen-specific T-cell factors.抗原特异性T细胞因子。
Immunology. 1980 Dec;41(4):759-87. doi: 10.1007/BF00199524.
2
Suppressor cells and immunoregulation.抑制细胞与免疫调节。
Annu Rev Immunol. 1984;2:127-57. doi: 10.1146/annurev.iy.02.040184.001015.
3
Regulation of immune responses: analysis with lymphocyte clones.免疫反应的调节：淋巴细胞克隆分析
Cell. 1981 Jul;25(1):7-8. doi: 10.1016/0092-8674(81)90226-9.
4
Ontogeny of MHC-linked, T cell-mediated suppression is regulated by the T cell genotype.与主要组织相容性复合体（MHC）相关的、T细胞介导的抑制作用的个体发生受T细胞基因型调控。
J Mol Cell Immunol. 1986;2(4):219-31.
5
Functional and molecular organisation of an antigen-specific suppressor factor from a T-cell hybridoma.来自T细胞杂交瘤的抗原特异性抑制因子的功能和分子组织
Nature. 1980 Jan 10;283(5743):227-8. doi: 10.1038/283227a0.
6
T helper and T suppressor cells are restricted by the A and E molecules, respectively, in the F antigen system.在F抗原系统中，辅助性T细胞和抑制性T细胞分别受A分子和E分子的限制。
Immunogenetics. 1985;22(2):169-75. doi: 10.1007/BF00563514.
7
Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c.小鼠细胞色素c的T细胞受体中Vα基因片段的主要使用情况。
Nature. 1986;324(6098):679-82. doi: 10.1038/324679a0.
8
Coexistence of variable region of immunoglobulin heavy chain and I region gene products on antigen-specific suppressor T cells and suppressor T cell factor. A minimal model of functional antigen receptor of T cells.
Mol Immunol. 1980 Jul;17(7):867-75. doi: 10.1016/0161-5890(80)90035-8.
9
Lymphocytes. 1. Function. Genetic restrictions in the immune response.淋巴细胞。1. 功能。免疫反应中的遗传限制。
J Clin Pathol Suppl (R Coll Pathol). 1979;13:30-8. doi: 10.1136/jcp.s3-13.1.30.
10
Antigen-specific suppression of human antibody responses by allogeneic T cells. I. Frequency and antigen specificity of allogeneic suppressor T cells and their role in major histocompatibility complex-controlled genetic restriction.同种异体T细胞对人抗体反应的抗原特异性抑制。I. 同种异体抑制性T细胞的频率和抗原特异性及其在主要组织相容性复合体控制的遗传限制中的作用。
J Exp Med. 1984 Apr 1;159(4):1225-37. doi: 10.1084/jem.159.4.1225.

引用本文的文献

1
From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: a History of Hapten-Specific T Suppressor Factor.从神秘的上清液实体到抗原特异性外泌体中的miRNA-150：半抗原特异性T抑制因子的历史
Arch Immunol Ther Exp (Warsz). 2015 Oct;63(5):345-56. doi: 10.1007/s00005-015-0331-4. Epub 2015 Feb 18.
2
Some properties and applications of monoclonal antibodies.单克隆抗体的一些特性与应用。
Biochem J. 1981 Oct 15;200(1):1-10. doi: 10.1042/bj2000001.
3
Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells.来自淋巴细胞的普遍存在的非免疫球蛋白对氨基苯砷酸结合分子。
J Exp Med. 1982 Feb 1;155(2):611-6. doi: 10.1084/jem.155.2.611.
4
Anti-tumor effects of an antiserum raised in syngeneic mice to a tumor-specific T suppressor factor.同基因小鼠中产生的针对肿瘤特异性T抑制因子的抗血清的抗肿瘤作用。
Cancer Immunol Immunother. 1982;13(2):134-9. doi: 10.1007/BF00205314.
5
Genetic control of the antibody response to poly(L Tyr, L Glu)-poly(DL Ala)--poly(L Lys) in mice: analysis of (low responder x low responder)F1 hybrids.小鼠对聚（L-酪氨酸，L-谷氨酸）-聚（DL-丙氨酸）-聚（L-赖氨酸）抗体反应的遗传控制：（低反应者×低反应者）F1杂种分析
Immunology. 1982 Feb;45(2):273-81.
6
T helper factor in contact sensitivity: antigen-specific I-A+ helper factor is made by an Lyt-1+2-, I-A+, I-J- T cell.接触敏感性中的辅助性T细胞因子：抗原特异性I-A+辅助因子由Lyt-1+2-、I-A+、I-J- T细胞产生。
Immunology. 1984 Jun;52(2):261-7.
7
H-2-restricted helper factor secreted by clone hybridoma cells.克隆杂交瘤细胞分泌的H-2限制性辅助因子。
J Exp Med. 1981 Sep 1;154(3):942-51. doi: 10.1084/jem.154.3.942.

本文引用的文献

1
Genetic restriction of the serum factor mediating tolerance in trinitrochlorobenzene hypersensitivity.介导三硝基氯苯超敏反应中耐受性的血清因子的遗传限制。
Cell Immunol. 1980 Mar 1;50(1):41-7. doi: 10.1016/0008-8749(80)90004-0.
2
Mechanism of antigen binding by T cells. H-2(I-A)-restricted binding of antigen plus Ia by helper cells.T细胞对抗原的结合机制。辅助细胞对抗原加Ia的H-2（I-A）限制性结合。
Eur J Immunol. 1980 Apr;10(4):273-81. doi: 10.1002/eji.1830100410.
3
Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
J Exp Med. 1980 May 1;151(5):1213-31. doi: 10.1084/jem.151.5.1213.
4
Genetic regulation of delayed-type hypersensitivity responses to poly(LTyr,LGlu)-poly(DLAla)--poly(LLys). II. Evidence for a T-T-cell collaboration in delayed-type hypersensitivity responses and for a T-cell defect at the efferent phase in nonresponder H-2k mice.对聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）--聚（L-赖氨酸）迟发型超敏反应的遗传调控。II. 非应答性H-2k小鼠迟发型超敏反应中T细胞与T细胞协作的证据及传出相T细胞缺陷的证据
J Exp Med. 1980 Mar 1;151(3):628-36. doi: 10.1084/jem.151.3.628.
5
Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor.抗原特异性T细胞因子对抗体应答抑制作用的细胞后果
J Exp Med. 1980 Mar 1;151(3):517-27. doi: 10.1084/jem.151.3.517.
6
Genetic regulation of delayed-type hypersensitivity responses to poly(LTyr,LGu)-poly(DLAla)--poly(LLys). I. Expression of the genetic defect at two phases of the immune process.对聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）--聚（L-赖氨酸）迟发型超敏反应的遗传调控。I. 免疫过程两个阶段遗传缺陷的表达
J Exp Med. 1980 Feb 1;151(2):265-74. doi: 10.1084/jem.151.2.265.
7
T-T hybridoma product specifically suppresses tumor immunity.T-T杂交瘤产物可特异性抑制肿瘤免疫。
Proc Natl Acad Sci U S A. 1980 May;77(5):2866-70. doi: 10.1073/pnas.77.5.2866.
8
Suppressor cells and the handling of antigen.抑制细胞与抗原处理
Immunol Rev. 1980;50:3-45. doi: 10.1111/j.1600-065x.1980.tb00306.x.
9
Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor.抗原特异性T细胞介导的抑制作用。五、H-2连锁基因对L-谷氨酸50-L-酪氨酸50抑制因子产生及活性中不同抗原特异性缺陷的控制。
J Exp Med. 1980 May 1;151(5):1245-59. doi: 10.1084/jem.151.5.1245.
10
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
J Exp Med. 1980 May 1;151(5):1183-95. doi: 10.1084/jem.151.5.1183.