Oncol Res Treat. 2018;41(11):693-696. doi: 10.1159/000494067. Epub 2018 Oct 17.
Uterine adenosarcoma is a rare malignancy. It is defined as a biphasic tumor composed of both sarcomatous stroma and benign epithelium. While the sarcomatous component usually is a low-grade homologous uterine sarcoma, the epithelium most often consists of endometrium-like cells. If the sarcomatous part occupies more than 25% of the tumor volume, the situation is referred to as sarcomatous overgrowth - accounting for about 10% of cases. While adenosarcoma usually may be considered a tumor of low malignant potential, the sarcomatous overgrowth most often presents as high-grade sarcoma and is associated with aggressive clinical behavior. Adenosarcomas stage I without sarcomatous overgrowth have a rather good prognosis, with a 5-year overall survival up to 80%. For treatment, complete surgical removal is advocated. Adjuvant chemotherapy and radiotherapy are not defined. Recurrences should again be treated surgically, attempting to achieve complete tumor resection. While the optimum medical treatment for relapsed and metastasized adenosarcomas has yet to be found, chemotherapy and endocrine therapy are potential options.
子宫腺肉瘤是一种罕见的恶性肿瘤。它被定义为一种由肉瘤基质和良性上皮组成的双相肿瘤。虽然肉瘤成分通常是低级同源性子宫肉瘤，但上皮通常由类似于子宫内膜的细胞组成。如果肉瘤部分占肿瘤体积的 25%以上，则称为肉瘤过度生长 - 约占病例的 10%。虽然腺肉瘤通常可被认为是一种低恶性潜能的肿瘤，但肉瘤过度生长通常表现为高级别肉瘤，并与侵袭性临床行为相关。没有肉瘤过度生长的 I 期腺肉瘤预后相当好，5 年总生存率高达 80%。治疗上，提倡完全手术切除。辅助化疗和放疗尚未明确。复发后应再次手术治疗，试图实现肿瘤完全切除。虽然尚未找到复发性和转移性腺肉瘤的最佳治疗方法，但化疗和内分泌治疗是潜在的选择。
