Adenosarcoma of uterus characterized by differentiation of rhabdomyosarcoma and chondrosarcoma: A case report and review of literature.

Although Müllerian adenosarcoma of the uterus shows weak malignant potential, there are still some factors indicating a worse prognosis. An incontinuous pelvic pain with urinary frequency, urgency, and hypouricemia arose in a mid-70s woman who refused to acknowledge the history of Tamoxifen use. A huge mass in the pelvis was found simultaneously by palpation, B-ultrasonography, and computed tomography. After a total hysterectomy was performed, a mass with a size of 10.5 cm × 8.5 cm × 8.5 cm was seen at the fundus of the uterus. The tumor consisted of a few benign epithelia and the majority of sarcomas, which mainly contained rhabdomyosarcoma and chondrosarcoma, and a small proportion of endometrial stromal sarcoma. Multifocal necrosis was noticed while the superficial muscular layer of the uterus was invaded. So Müllerian adenosarcoma of the uterus was given to the patient. Eight months after the operation, the patient died from respiratory failure due to pulmonary metastasis. It is suggested that sarcomatous overgrowth, the presence of heterologous elements, especially rhabdomyosarcoma and chondrosarcomatous, myoinvasion, and necrosis, may be histological factors indicating an adverse prognosis.