Harvey W, Kamin S, Meghji S, Wilson M
Immunology. 1987 Mar;60(3):415-8.
This paper describes the activity of a bacterial surface component (capsular material, CM) in biological assays for interleukin-1 (IL-1). CM from the periodontal pathogen Haemophilus actinomycetemcomitans was tested in the following in vitro assays: mouse thymocyte proliferation (LAF assay), stimulation of collagenase and prostaglandin (PG) E2 synthesis by articular chondrocytes, and stimulation of PGE2 synthesis by fibroblasts. In all these assays, CM gave a response similar to an IL-1 preparation. This ability to mimic IL-1 suggests an important role for CM in both cell-mediated immunity and connective tissue destruction in localized juvenile periodontitis (LJP).
本文描述了一种细菌表面成分(荚膜物质,CM)在白细胞介素-1(IL-1)生物学检测中的活性。对来自牙周病原体伴放线放线杆菌的CM进行了以下体外检测:小鼠胸腺细胞增殖(淋巴细胞激活因子检测)、关节软骨细胞对胶原酶和前列腺素(PG)E2合成的刺激,以及成纤维细胞对PGE2合成的刺激。在所有这些检测中,CM产生的反应与IL-1制剂相似。这种模拟IL-1的能力表明CM在局限性青少年牙周炎(LJP)的细胞介导免疫和结缔组织破坏中均发挥重要作用。