单核细胞衍生的白细胞介素1α和白细胞介素1β在培养的小鼠胸腺细胞和培养的人结缔组织细胞上的特定生物活性彼此相似。
Specific bioactivities of monocyte-derived interleukin 1 alpha and interleukin 1 beta are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells.
作者信息
Rupp E A, Cameron P M, Ranawat C S, Schmidt J A, Bayne E K
出版信息
J Clin Invest. 1986 Sep;78(3):836-9. doi: 10.1172/JCI112649.
Abstract
In this report we compare the bioactivities of pure, human monocyte-derived interleukin 1 (IL-1) alpha and beta in the standard murine thymocyte proliferation assay, a human dermal fibroblast proliferation assay, and in an assay measuring stimulation of prostaglandin E2 (PGE2) release from human rheumatoid synoviocytes. In each case the different species of IL-1 produced saturable stimulation and gave similar dose response curves. Half-maximal stimulation was observed at average IL-1 concentrations of 29 pM in the thymocyte assay, 2 pM in the dermal fibroblast proliferation assay, and 5 pM in the synovial cell assay. Our results show that native, monocyte-derived IL-1 alpha and IL-1 beta are both potent stimulators of connective tissue cells and that the specific bioactivities of these molecules are similar to each other in tests on human connective tissue cells, as well as on murine lymphoid cells.
摘要
在本报告中，我们在标准的小鼠胸腺细胞增殖试验、人皮肤成纤维细胞增殖试验以及测量人类风湿滑膜细胞释放前列腺素E2（PGE2）的试验中，比较了纯的、人单核细胞衍生的白细胞介素1（IL-1）α和β的生物活性。在每种情况下，不同种类的IL-1均产生饱和刺激，并给出相似的剂量反应曲线。在胸腺细胞试验中，平均IL-1浓度为29 pM时观察到半数最大刺激；在皮肤成纤维细胞增殖试验中为2 pM；在滑膜细胞试验中为5 pM。我们的结果表明，天然的、单核细胞衍生的IL-1α和IL-1β都是结缔组织细胞的有效刺激剂，并且在对人结缔组织细胞以及小鼠淋巴细胞的测试中，这些分子的特定生物活性彼此相似。
相似文献
1
Specific bioactivities of monocyte-derived interleukin 1 alpha and interleukin 1 beta are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells.单核细胞衍生的白细胞介素1α和白细胞介素1β在培养的小鼠胸腺细胞和培养的人结缔组织细胞上的特定生物活性彼此相似。
J Clin Invest. 1986 Sep;78(3):836-9. doi: 10.1172/JCI112649.
2
Identification of a high-affinity receptor for interleukin 1 alpha and interleukin 1 beta on cultured human rheumatoid synovial cells.
J Clin Invest. 1988 Aug;82(2):420-6. doi: 10.1172/JCI113614.
3
Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: involvement of membrane-associated cytokines.滑膜细胞和成纤维细胞与活化的T淋巴细胞直接接触后，间质胶原酶与金属蛋白酶组织抑制剂1之间的失衡：膜相关细胞因子的作用
Arthritis Rheum. 1998 Oct;41(10):1748-59. doi: 10.1002/1529-0131(199810)41:10<1748::AID-ART7>3.0.CO;2-3.
4
Induction of human interleukin 1 mRNA measured by collagenase- and prostaglandin E2-stimulating activity in rheumatoid synovial cells.通过类风湿性滑膜细胞中胶原酶和前列腺素E2刺激活性来测定人白细胞介素1信使核糖核酸的诱导情况。
Eur J Immunol. 1984 Oct;14(10):898-901. doi: 10.1002/eji.1830141007.
5
6
7
8
Interleukin-1 and transforming growth factor-alpha: synergistic stimulation of metalloproteinases, PGE2, and proliferation in human fibroblasts.白细胞介素-1与转化生长因子-α：对人成纤维细胞中金属蛋白酶、前列腺素E2及增殖的协同刺激作用
Exp Cell Res. 1994 Feb;210(2):166-71. doi: 10.1006/excr.1994.1025.
9
Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium.类风湿性关节炎和骨关节炎滑膜中组织蛋白酶K和S表达的比较。
Arthritis Rheum. 2002 Mar;46(3):663-74. doi: 10.1002/art.10114.
10
p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.p55和p75肿瘤坏死因子受体在滑膜成纤维细胞和其他成纤维细胞中表达并介导共同功能。
Eur Cytokine Netw. 1994 Sep-Oct;5(5):441-8.
引用本文的文献
1
Systems-wide analysis unravels the new roles of CCM signal complex (CSC).全系统分析揭示了CCM信号复合体（CSC）的新作用。
Heliyon. 2019 Dec 2;5(12):e02899. doi: 10.1016/j.heliyon.2019.e02899. eCollection 2019 Dec.
2
Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury.上肢重复性劳损患者屈肌腱中白细胞介素-1β、P 物质、结缔组织生长因子和腱病的暴露依赖性增加。
J Orthop Res. 2010 Mar;28(3):298-307. doi: 10.1002/jor.20984.
3
High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries.通过筛选重组肽文库发现的高亲和力I型白细胞介素1受体拮抗剂。
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7381-6. doi: 10.1073/pnas.93.14.7381.
4
Differential responses of old human cartilage explants to synovial- and mononuclear-cell factors.老年人类软骨外植体对滑膜细胞和单核细胞因子的不同反应。
Rheumatol Int. 1987;7(5):223-9. doi: 10.1007/BF00541381.
5
Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.白细胞介素1：一种人类血管平滑肌细胞的促有丝分裂原，可诱导生长抑制性前列腺素的释放。
J Clin Invest. 1988 Feb;81(2):487-98. doi: 10.1172/JCI113346.
6
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.类风湿关节炎中白细胞介素-1和肿瘤坏死因子信使核糖核酸的表达：白细胞介素-1α的持续产生
Clin Exp Immunol. 1988 Sep;73(3):449-55.
7
Mechanism of anaemia in rheumatoid arthritis: demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro.类风湿关节炎贫血的机制：贫血患者白细胞介素1β浓度升高以及白细胞介素1在体外介导对正常红细胞生成和人红白血病（HEL）细胞增殖的抑制作用的证明。
Ann Rheum Dis. 1988 Dec;47(12):972-8. doi: 10.1136/ard.47.12.972.
8
Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.白细胞介素1抑制人软骨细胞中软骨特异性II型和IX型胶原蛋白的表达，并增加I型和III型胶原蛋白的表达。
J Clin Invest. 1988 Dec;82(6):2026-37. doi: 10.1172/JCI113823.
9
Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein.人重组白细胞介素-1调节硫酸皮肤素蛋白聚糖核心蛋白的细胞mRNA水平。
Biochem J. 1988 May 15;252(1):309-12. doi: 10.1042/bj2520309.
10
Identification of a high-affinity receptor for interleukin 1 alpha and interleukin 1 beta on cultured human rheumatoid synovial cells.
J Clin Invest. 1988 Aug;82(2):420-6. doi: 10.1172/JCI113614.
本文引用的文献
1
In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor.一种人白细胞介素-1样因子对人软骨细胞和滑膜细胞的体外激活作用。
Arthritis Rheum. 1984 Jun;27(6):654-62. doi: 10.1002/art.1780270608.
2
An interleukin 1 like factor stimulates bone resorption in vitro.一种白细胞介素-1样因子在体外刺激骨吸收。
Nature. 1983;306(5941):378-80. doi: 10.1038/306378a0.
3
Interleukin 1, a potential regulator of fibroblast proliferation.白细胞介素1，一种成纤维细胞增殖的潜在调节因子。
J Immunol. 1982 May;128(5):2177-82.
4
Interleukin-1.白细胞介素-1
Rev Infect Dis. 1984 Jan-Feb;6(1):51-95. doi: 10.1093/clinids/6.1.51.
5
Purification and partial biochemical characterization of normal human interleukin 1.正常人白细胞介素1的纯化及部分生化特性分析
J Exp Med. 1984 Sep 1;160(3):772-87. doi: 10.1084/jem.160.3.772.
6
Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis.二氧化硅刺激的单核细胞释放与白细胞介素1相同的成纤维细胞增殖因子。白细胞介素1在矽肺发病机制中的潜在作用。
J Clin Invest. 1984 May;73(5):1462-72. doi: 10.1172/JCI111350.
7
Rheumatoid synovial cell morphologic changes induced by a mononuclear cell factor in culture.培养中单核细胞因子诱导的类风湿性滑膜细胞形态学变化
Arthritis Rheum. 1983 Jan;26(1):8-14. doi: 10.1002/art.1780260102.
8
Interleukin 1 stimulation of collagenase production by cultured fibroblasts.白细胞介素1对培养的成纤维细胞产生胶原酶的刺激作用。
J Exp Med. 1983 Feb 1;157(2):801-6. doi: 10.1084/jem.157.2.801.
9
Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).部分纯化的淋巴细胞激活因子（白细胞介素1）对类风湿性滑膜细胞胶原酶和前列腺素产生的刺激作用。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2474-7. doi: 10.1073/pnas.78.4.2474.
10
Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.猪分解代谢素是白细胞介素1的一种形式。软骨和骨吸收，成纤维细胞产生前列腺素和胶原酶，并且胸腺细胞增殖会因一种蛋白质而增强。
Biochem J. 1984 Dec 1;224(2):461-6. doi: 10.1042/bj2240461.
Zotero 插件