Department of Pediatrics, Selçuk University Medical School, Konya, Turkey.
Department of Pediatric Rheumatology, Selçuk University Medical School, Konya, Turkey.
Clin Rheumatol. 2019 Mar;38(3):701-707. doi: 10.1007/s10067-018-4338-1. Epub 2018 Oct 16.
In this study, we aimed to investigate whether neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) might be helpful in the diagnosis of subclinical inflammation of familial Mediterranean fever (FMF). Clinical, laboratory, and genetic results of the patients who were followed up with the diagnosis of FMF were obtained retrospectively from the hospital files and recorded to standardized form. Age- and sex-matched healthy subjects were included as the control group. Eighty-three of the 143 patients (58.0%) were male and 60 (42.0%) were female. The mean age of our patients was 164.62 ± 51.20 months and the mean age of the control group was 164.92 ± 51.10 months. The mean diagnosis age of our patients was 98.10 ± 49.11 months. The mean follow-up time of the patients was 66.03 ± 36.37 months. 91.60% of our patients had abdominal pain, 78.32% fever, and 28.67% joint pain. The mean NLR of the patients was significantly higher than the mean levels at attack-free period and the control group. However, no statistically significant difference was found between the mean levels at attack-free period and the control group. MPV levels were statistically significantly high during acute attack when compared with the control group. However, they showed no statistically significant difference between acute attack and attack-free period. NLR is a useful marker to predict inflammation in FMF patients. However, our results did not support the idea that MPV might reflect acute attack and attack-free period.
在这项研究中，我们旨在探讨中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）和平均血小板体积（MPV）是否有助于诊断家族性地中海热（FMF）的亚临床炎症。从医院档案中回顾性获取并记录符合 FMF 诊断标准的患者的临床、实验室和遗传结果，并将其录入标准化表格。年龄和性别匹配的健康受试者被纳入对照组。在 143 名患者中，83 名（58.0%）为男性，60 名（42.0%）为女性。我们患者的平均年龄为 164.62±51.20 个月，对照组的平均年龄为 164.92±51.10 个月。我们患者的平均诊断年龄为 98.10±49.11 个月。患者的平均随访时间为 66.03±36.37 个月。91.60%的患者有腹痛，78.32%有发热，28.67%有关节痛。患者的平均 NLR 明显高于无发作期和对照组的平均水平。然而，无发作期和对照组之间的平均水平无统计学差异。与对照组相比，急性发作时 MPV 水平明显升高。然而，急性发作期与无发作期之间无统计学差异。NLR 是预测 FMF 患者炎症的有用标志物。然而，我们的结果不支持 MPV 可能反映急性发作和无发作期的观点。
