Palombo C, Marabotti C, Genovesi-Ebert A, Del Chicca M G, Balzan S, Giaconi S, Fommei E, Gazzetti P, Clerico A, Ghione S
J Hypertens Suppl. 1986 Dec;4(5):S461-4.
Evidence has been provided on the increased presence, in essential hypertension, of endogenous digitalis-like factor(s) [DLIS, digoxin-like immunoreactive substance(s)] able to cross-react with antidigoxin antibodies and to inhibit the membrane-bound sodium-potassium pump. An inhibition of the sodium pump could lead, in smooth muscle cells, to an increase of intracellular calcium ions and to an increase of total peripheral resistances. In this study the relation between plasma levels of DLIS and the acute hypotensive effect of a calcium antagonist (nifedipine) has been evaluated in a group of borderline to severe hypertensive patients and in a control group of normotensive subjects. The results obtained confirm that the hypotensive effect of nifedipine is related to pretreatment blood pressure and show, only in hypertensive patients, a significant relation of DLIS with both pretreatment blood pressure and blood pressure decrement induced by nifedipine. These findings are compatible with a possible role of DLIS in modulating cellular calcium handling.
已有证据表明，在原发性高血压患者体内，内源性洋地黄样因子（DLIS，地高辛样免疫反应物质）的含量增加，这些因子能够与抗地高辛抗体发生交叉反应，并抑制膜结合钠钾泵。钠泵的抑制作用在平滑肌细胞中可能导致细胞内钙离子增加以及总外周阻力增加。在本研究中，对一组临界至重度高血压患者和一组正常血压对照受试者评估了DLIS血浆水平与钙拮抗剂（硝苯地平）急性降压效果之间的关系。所得结果证实硝苯地平的降压效果与治疗前血压有关，并且仅在高血压患者中显示出DLIS与治疗前血压以及硝苯地平引起的血压下降均存在显著关系。这些发现与DLIS在调节细胞钙处理方面可能发挥的作用相符。
