Martinka E
I. interná klinika MFN, Martin.
Vnitr Lek. 1995 Sep;41(9):637-43.
Endogenous digitalis-like substances (EDLS) present endogenous products which structurally belong to cardiac glycosides (CG). According contemporary views these substances potentially present a newly discovered hormonal group produced by adrenal cortex. EDLS, similarly exogenous CG, bind to specific CG- receptor of Na(+)-K(+)-ATPase and inhibit activity of this enzyme. At the cellular level, EDLS lead to increase in intracellular calcium storing and such may play an important role in modulation of calcium-dependent processes and their response to characteristic stimuli (e.g. contractility of vascular smooth muscle cells, hormonal secretion etc.). First part is a review of present views to character and cellular effects of EDLS.
内源性类洋地黄物质（EDLS）是一类内源性产物，其结构上属于强心苷（CG）。根据当代观点，这些物质可能是肾上腺皮质产生的一个新发现的激素组。与外源性CG类似，EDLS与Na(+)-K(+)-ATP酶的特异性CG受体结合并抑制该酶的活性。在细胞水平上，EDLS导致细胞内钙储存增加，这可能在调节钙依赖性过程及其对特征性刺激的反应（如血管平滑肌细胞的收缩性、激素分泌等）中起重要作用。第一部分是对EDLS的特性和细胞效应的当前观点的综述。
