酮康唑和伊曲康唑对卵圆形糠秕孢子菌生长及甾醇合成的影响。
Effects of ketoconazole and itraconazole on growth and sterol synthesis in Pityrosporum ovale.
作者信息
Marichal P, Gorrens J, Van Cutsem J, Van Gerven F, Vanden Bossche H
出版信息
J Med Vet Mycol. 1986 Dec;24(6):487-9. doi: 10.1080/02681218680000781.
PMID:3033190
Abstract
The effects of ketoconazole and itraconazole on growth and sterolsynthesis in Pityrosporum ovale was studied. Itraconazole was at least 10 times more active than ketoconazole. Sterol synthesis was inhibited more rapidly than growth, suggesting that the antifungal activity of both azoles originates from an effect on the 14 alpha demethylase system, as seen in other species.
摘要
研究了酮康唑和伊曲康唑对卵圆形糠秕孢子菌生长及甾醇合成的影响。伊曲康唑的活性至少比酮康唑高10倍。甾醇合成比生长受到更快速的抑制，这表明这两种唑类的抗真菌活性源自对14α-脱甲基酶系统的作用，正如在其他菌种中所见。
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